Age Related Hearing Loss Could Potentially Receive FDA Approval

The first ever medication to treat age-related hearing loss could potentially receive FDA approval through a comprehensive study being conducted at the University of South Florida. Robert Frisina, Ph.D., chair of the USF Medical Engineering Department and director of the USF Global Center for Hearing and Speech Research, and his team were awarded a U.S. patent for his theory that you can slow hearing loss by combining supplements for the hormone aldosterone with anti-inflammatory medications, such as aspirin or ibuprofen.

Naturally-occurring steroid

Aldosterone is a naturally-occurring steroid that influences sodium and potassium regulation in the body, including the inner ear used for hearing.  Its level typically decreases as we age, impacting auditory perception. “Our novel idea, embodied in the new patent, involves boosting aldosterone to young adult levels, to make the ear “young” again.” said Frisina. The research is part of a five-year, $9 million grant awarded from the National Institutes of Health to USF’s Global Center. Since its renewal launch in 2016, the study has include pre-clinical trials on mice.

Hearing loss, also known as hearing impairment, is a partial or total inability to hear. A deaf person has little to no hearing. Hearing loss may occur in one or both ears. In children, hearing problems can affect the ability to learn spoken language and in adults it can create difficulties with social interaction and at work. In some people, particularly older people, hearing loss can result in loneliness. Hearing loss can be temporary or permanent.

Age related hearing loss

The aging mice receive subcutaneous, time release aldosterone treatments for 4 months; equivalent to about 7-8 years of treatment for people. Frisina and his colleagues found untreated aging mice experience a 50 percent decline in aldosterone compare to young adult mice. However, following treatment, the levels rose to a near normal range. It’s important to note that the hormone supplement; which did not induce potential negative side effects, such as elevating blood pressure. Most importantly, the treat mice did not undergo age-related hearing loss; during the study, whereas the control mice did suffer from continue age link hearing impairment.

Frisina’s team is now in the process of licensing the patent and if successful; which will then conduct four levels of FDA human clinical trials in collaboration with the pharmaceutical company doing the licensing. Once the drug is FDA-approve, it would then be available to the public. Its eventual commercialization could be life-changing for many; so as age-relate hearing loss is the number one communication disorder of our elderly population and impacts more people than any other neurodegenerative disease of aging.