Trans generational

Trans generational bisphenol A (BPA) exposure may contribute to autism, according to a mouse study published in the Endocrine Society’s journal Endocrinology. Endocrine disrupting chemicals (EDCs) are chemicals or mixtures of chemicals that interfere with the way the body’s hormones work.

Bisphenol A has document trans generational effects on social behavior, heart, and reproductive functions, thus, removing BPA from all products will not eliminate longterm effects (20-24). It is important to keep in mind that with gestational exposure to any substance, the offspring (F1) have experience direct actions of the compound during development.

Animals are trans generational

When they mature and breed, the second generation (F2) is produce from germ cells that were likewise expose to the substance during F1 gestation. They examine the third generation (F3), as these are the first offspring without any direct exposure to BPA. Effects in these animals are trans generational and expect to continue in subsequent generations.

The fundamental causes of mental health disorders are deficits and abnormalities in neural function, which are likely produce by a large number of mechanisms. BPA has been associate with alterations in spine post-synaptic densities (PSD) (25-28) and synaptic plasticity. Effects of BPA might, at least in part; so be cause by perturbation of ionotropic and/or metabotropic glutamate receptors.

BPA is a common EDC use in plastics and food storage material, and it is already present in most humans’ urine or blood. Animal studies have link BPA to anxiety, aggression, and poor learning and social interactions. Studies of human populations report associations between BPA and neurobehavioral issues like attention deficit hyperactivity disorder and autism.

Nerve cell connections

Exposure of mouse fetuses to BPA disrupts formation of nerve cell connections in the brain; also this is a transgenerational effect. To put this in human terms, if your great grandmother was expose to BPA; so during her pregnancy and none of your other relatives ever came into contact with BPA, your brain would still show these effects. In this mouse study, researchers tested mice descend from those expose to BPA for social recognition; also find that they showed a social behavioral deficient like autistic behavior.

Mice whose great grandmothers were expose to BPA during pregnancy; so were more active and took longer to habituate to strangers than other mice.  More strikingly, they didn’t explore the new mice that were introduced to the group. Mice are very social and curious, so this is an exciting finding. Even if we ban all BPA right now, that will not change these long-term effects on the brain,” Rissman said.