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Itchy Skin Could Be Warning Sign Of Diabetes

Diabetes symptoms include frequent urination and unexplained weight loss, but itchy skin could also be an early warning sign. Diabetes is a lifelong condition that causes a person's blood sugar level to become too high.

Most people with type-1 diabetes are born with the condition, while type-2 can come on at any time. Type-2 diabetes develops when the body becomes resistant to insulin or when the pancreas stops producing enough insulin.

Type-2 Diabetes

Common type-2 diabetes symptoms include frequent urination, a sudden increase in appetite, moods swings and problems sleeping. But there are some other ways to spot the early warning signs of the disease.

Selective Inhibitor Of Ceramide Synthase 1 Reveals a Novel Role In Fat Metabolism

A novel drug is being touted as a major step forward in the battle against Australia's escalating rates of obesity and associated metabolic diseases. As it stands, 2 in 3 adults in Australia are classified as being overweight or obese.

A long-term study between researchers at the Centenary Institute and UNSW Sydney has led to the creation of a drug which targets an enzyme-linked to insulin resistance a key contributor of metabolic diseases, such as Type II diabetes.

Together, they set out to create a drug that targeted enzymes within the Ceramide Synthase family, which produce lipid molecules believed to promote insulin resistance in skeletal muscle, as well as liver and fat tissue. The study was published in the highly-regarded scientific journal Nature Communications

Resistance Exercises Improves Insulin Resistance, Glucose Levels

Research has looked at the molecules that result in this contradiction. Exercise is associated with skeletal muscle inflammation, yet physical activity has beneficial effects on type 2 diabetes (T2D). Skeletal muscle inflammation is emerging as a potential contributor to T2D. Inflammation occurs during exercise and repair and it is also a hallmark of myopathies, a number of conditions that cause muscle weakness. This suggests that exercise has a crucial role in keeping the glucose levels balanced in skeletal muscle.

Systemic Thyroid Hormone Status During Levothyroxine Therapy In Hypothyroidism

A study of overt hypothyroidism in which participants were treated with levothyroxine to normalize serum TSH levels and measured other objective markers of thyroid hormone signaling. The standard of care for overt hypothyroidism is levothyroxine at doses that normalize serum TSH levels. Whether this approach universally restores thyroid hormone signaling is unknown. The study was published in The Journal of Clinical Endocrinology & Metabolism.

Age Not Obesity Causes Diabetes Epidemic in Guatemala, Findings

The diabetes epidemic in Guatemala is worse than previously thought: more than 25% of its indigenous people, who make up 60% of the population, suffer from type 2 diabetes or pre-diabetes, suggests a new study published in PLOS ONE. That's almost double the rate from a diabetes estimation back in 2003. The team also found that the driving force behind the epidemic is not obesity – most often associated with an increased risk of the disease elsewhere in the world – but aging.

Effect Of Vitamin D3 And Periodontitis In Developing Type 2 Diabetes

Research has identified how vitamin D3 and periodontitis influence Type 2 diabetes. They found increased odds of developing Type 2 diabetes among people with gum disease who are also lacking in vitamin D3.

The study, published in BMJ Open Diabetes Research and Care. Participants were over the age of 30, and health interviews and physical measurements were conducted in-home and at a mobile examination centre.

Smoking Cessation, Weight Change, Type 2 Diabetes, And Mortality

According to a new study, the researcher examined weight gain after smoking cessation attenuates the health benefits of quitting is unclear. People who gain weight after they quit smoking may face a temporary increase in the risk of developing type 2 diabetes, with the risk directly proportional to the weight gain.

But regardless of weight gain, quitters can reap significant health benefits, including lower risk of cardiovascular disease, cancer, and early death. The study was published in the New England Journal of Medicine.

Obese Patients With PTSD Leads To Increased Risk Of Diabetes

Research finds post-traumatic stress disorder does not directly lead to type 2 diabetes mellitus (T2DM), instead, obesity in PTSD patients accounts for the increased risk. The study, "The Role of Obesity in the Association Between Posttraumatic Stress Disorder and Incident Diabetes" was published in JAMA Psychiatry.

Post-traumatic stress disorder is associated with risk factors for type 2 diabetes, including poor diet, lack of exercise, alcohol abuse and obesity. The risk factors may interact with hypothalamic-pituitary-adrenal changes to increase the risk of type 2 diabetes.

PCOS Patients With Insulin Resistance Decreased Cortisol Levels

A new study has shown that polycystic ovary syndrome (PCOS) patients with insulin resistance (IR) have decreased oxidation of cortisol and defects of insulin signaling in the endometrium.

In addition, local cortisol elevation, derived from the reduction of 11β-hydroxysteroid dehydrogenases (11β-HSD) 2, may influence the development of endometrial IR through the inhibition of the insulin signaling pathway via induction of phosphatase and tensin homolog deleted on chromosome ten (PTEN) expression in endometrial epithelial cells (EECs).