Super-enhancers (SEs) are unique areas of the genome which drive high-level of transcription; and play a pivotal role in the cell physiology. Previous studies have established several important genes in cancer as SE-driven oncogenes. It is likely that oncogenes may hack the resident tissue regenerative program; and interfere with SE-driven repair networks, leading to the…
One in ten people over 40 in the UK is now living with a diagnosis of Type 2 diabetes; according to new analysis released today by Diabetes UK. The new figures show that there are 3.8 million people living with a diagnosis of diabetes in the UK; and 90 per cent of those with Type 2.…
Estrogen in the brain is important to keep neurons communicating and memories being made, scientists report. Neurons in both males and females make estrogen and the scientists have shown that when they don’t, their brains have significantly less dense spines and synapses both key communication points for neurons in the biggest part of their brain, called the…
Mayo Clinic researchers have identified a gene called “UCP-1”; that may predict the development of pancreatic cancer in people with Type 2 diabetes. Their findings are published in Gastroenterology. “Developing strategies for the early detection of pancreatic cancer; so in people without symptoms is critical for improving survival,” says Suresh Chari, M.D.; a Mayo Clinic…
The Endocrine Society objects to the administration’s decision to severely restrict access to the Title X Family Planning Program, the nation’s only program for affordable birth control and reproductive care. The Title X program is essential in helping ensure that every person; regardless of income, identity, or whether or not they have health insurance; can…
A UC San Francisco study of human and mouse pancreatic tissue; suggests a new origin story for type 1 (T1) diabetes. The findings flip current assumptions about the causes of the disease; on their head and demonstrate a promising new preventative strategy that dramatically reduced disease risk in laboratory animals. T1 diabetes is an autoimmune…
Diabetes is a prime example of an enormous health care problem; the only solution of which is advanced technology aiming precise treatment optimization. Classic studies have shown that the numerous complications of diabetes; can be reduced by strict control, typically assessed by hemoglobin A1c. However, the risk of low blood sugar levels (i.e. hypoglycemia) remains…
The U.S. Food and Drug Administration today permitted marketing of the Tandem Diabetes Care t:Slim X2 insulin pump; with interoperable technology (interoperable t:Slim X2) for delivering insulin under the skin for children; and adults with diabetes. This new type of insulin pump, referred to as an alternate controller enabled (ACE) infusion pump, or ACE insulin…
A new study has revealed that testosterone, which is produced and released by the testes, is not the only hormone involved in fetal development of the penis. It is now thought that the masculinization process also involves a hormone called androsterone, which originates in other tissues, including the placenta. The results not only shed light…
In the current issue of Cardiovascular Innovations and Applications (Special Issue on Stable Ischemic Heart Disease, Volume 3, Number 3, 2019, pp. 285-290(6); DOI: https://doi.org/10.15212/CVIA.2017.0073 Cody Schwartz and David Winchester from the Malcom Randall VAMC, Gainesville, FL, USA consider diabetes mellitus and stable ischemic heart disease. More than 30 million Americans have diabetes mellitus (DM), and heart…
Researchers at Okayama University show how specific cells of the pancreas can facilitate cancer progression. Pancreatic cancer can be fatal. It is extremely difficult to treat partly because its precise growth mechanism is not clear. One of the characteristics of pancreatic cancer is the presence of fibrous structures or “desmoplasia”; that are found in conjunction…
;Researchers at Zhenjiang University School of Medicine, China have found that disruption in the microbial composition of the tongue coating could serve as a biomarker for early-stage pancreatic cancer. The study showed that the tongue-coating microbiomes of patients with early-stage pancreatic were significantly more diverse; and composed of remarkably different bacteria, compared with the tongue…