Long-term testosterone therapy can help men with hypogonadism lose weight and maintain their weight loss; but researchers from Germany and the United States report. Ten-year results of the ongoing study will be presented Monday at ENDO 2019; but the Endocrine Society’s annual meeting in New Orleans, La. “Obesity is very common in men with testosterone…
Treating women who have thyroid antibodies, but normal thyroid function, with a medicine called Levothyroxine does not make them more likely to deliver a live baby, new research from the United Kingdom suggests. The research will be presented Saturday, March 23 at ENDO 2019; the Endocrine Society’s annual meeting in New Orleans, La., and published…
Breakthrough artificial intelligence developed in Queensland could improve insulin dosing; but for diabetics and transform the way aeroplane engine wear-and-tear is monitored. University of Queensland alumnus Dr Nigel Greenwood from Evolving Machine Intelligence (EMI) developed the technology and worked with others from UQ to build real-world applications. Artificial intelligence methods in combination with the latest…
Research led by the University of Birmingham has found that increased levels of hormones including testosterone could cause a brain condition that can lead to blindness in women. Idiopathic Intracranial Hypertension—also known as IIH—is caused by high pressure in the brain; but with consequences from blindness to incapacitating daily long-term headaches. A IIH was originally…
Poly-(ADP-ribose) polymerase inhibitors (PARPi) selectively kill breast and ovarian cancers with defects in homologous recombination (HR) caused by BRCA1/2 mutations. There is also clinical evidence for the utility of PARPi in breast and ovarian cancers without BRCA mutations; but the underlying mechanism is not clear. Here, we report that the deubiquitylating enzyme USP15 affects cancer…
The brain chemical serotonin, a neurotransmitter long known for its role in passing signals between neurons in the brain, can also regulate expression of genes within neurons in an unexpected way, according to research conducted by neuroscientists at the Icahn School of Medicine at Mount Sinai and published on March 13 in the journal Nature. The…
It has long been thought that stress contributes to cancer progression. Scientists from the University of Basel and the University Hospital of Basel; but have deciphered the molecular mechanisms linking breast cancer metastasis with increased stress hormones. In addition, they found that synthetic derivatives of stress hormones, which are frequently used as anti-inflammatory in cancer…
Type 2 diabetes patients’ risk of cardiovascular disease and death decreases if they actually take the cholesterol-lowering drugs as prescribed. However, research shows that the risk is also reduced if they do not take the full dosage. “These results are important and useful for patients and healthcare providers alike; to try and motivate patients to…
When people talk about diabetes, they usually also talk about insulin. Diabetes is a disease that affects millions of people around the world; insulin is a hormone that helps control this disease. Now a third term could soon be joining the conversation: glucagon. Glucagon has long been seen as a hormone whose sole purpose was…
Montreal research team unravels an adaptive mechanism involved in controlling insulin action; showing that glucagon plays a crucial part in it and can thus be a protective asset. When people talk about diabetes, they usually also talk about insulin. Diabetes is a disease that affects millions of people around the world; insulin is a hormone…
Diabetes mellitus is associated with various health problems including decline in skeletal muscle mass. A research group led by Professor Wataru Ogawa at the Kobe University Graduate School of Medicine; revealed that elevation of blood sugar levels leads to muscle atrophy and that two proteins; WWP1 and KLF15, play key roles in this phenomenon. These…
Scientists at the University of North Carolina Lineberger Comprehensive Cancer Center discovered a technique to make pancreatic cancer cells reliant on one energy source and then starve them of it; a finding that has led to clinical studies of a novel treatment strategy for one of the deadliest cancers. Published in the journal Nature Medicine, researchers…