All news from Dermatology

Leg Ulcers Requires Punch Biopsies

Leg ulcers can be caused by vasculitis, pressure sores, inflammatory diseases, traumatic injuries, and cutaneous neoplasms which are often misdiagnosed as skin ulcers, write Lidia Sacchelli and colleagues in the September 19 online issue of the Journal Dermatopathology

Demand For Actinic Keratosis Treatments Tises

The number of actinic keratosis lesions treated in the Medicare population increased by about 20 percent between 2007 and 2015, according to a billing claims analysis. However, during the same time period, the mean inflation-adjusted payments per 1,000 Medicare Part B fee-for-service beneficiaries decreased from $11,749 to $10,942, due to reimbursement reductions to control the rising costs of actinic keratosis treatment.

BH3 Mimetics Induce Apoptosis Independent Of DRP-1 In Melanoma

Think of the protein BH3 like a finger that turns off to cancer cell survival switch. The problem is that most cancer cells have found ways to remove this "finger commonly, by breaking the action of a gene called p53 that puts the BH3 finger in motion.

Now think of Bcl-2 as the switch itself. When cancer breaks p53, the BH3 finger never moves, and the Bcl-2 survival switch remains on. Despite thousands of published studies, researchers have not had much luck directly protecting the action of p53. But, BH3 is another story.

The study was published in the journal Cell Death and Disease.