All news from Dermatology

Therapy For Melanoma

Researchers Have Identified Biomarker And New Therapy For Melanoma.

Microphthalmia-associated transcription factor is the most characterized member of the MIT family. Its gene resides at the mi locus in mice, and its protumorogenic targets include factors involved in cell death, DNA replication, repair, mitosis, microRNA production, membrane trafficking, mitochondrial metabolism, and much more. Mutation of this gene results in deafness, bone loss, small eyes, and poorly pigmented eyes…

Acne

Acne's possible new roots in growing glands and undigested collagen

It turns out undigested collagen blocking growing gland cells might sometimes be causing the blackheads seen in common acne, not just excess sebum, as had long been assumed. After the publication of a 2018 paper, researchers suggest genetic mutations that inhibit the collagen reshaping process could be one of the underlying culprits in acne. The…

Atopic dermatities

New Potential Approach To Treat Atopic Dermatitis

Responsibilities of Immune system to fungi on our skin, Researchers at the University of Zurich have demonstrated that the same immune cells that protect us against skin fungi also encourage the inflammatory symptoms of atopic dermatitis. An antibody therapy could alleviate this chronic inflammatory skin disease. The skin of humans and animals is densely populate…

Alopecia areata

Another JAK Inhibitor Shows Promise For Alopecia Areata

The Janus kinase (JAK) inhibitor CTP-543 (Concert Pharmaceuticals) is effective for the treatment of moderate to severe alopecia areata; so as per interim results from a phase 2a randomized safety and efficacy study. They’ve identified our minimally effective dose, James Cassella, PhD, chief development officer at Concert. The autoimmune disease affects about 650,000 people in…

atopic dermatities

Scientists Demonstrate Role Of Salt In Atopic Dermatitis

Salt apparently affects allergic immune reactions. A team working with Prof. Christina Zielinski at the Technical University of Munich (TUM) has demonstrated in cell cultures that salt leads to the formation of Th2 cells. These immune cells are active in allergic conditions such as atopic dermatitis. The team also detected elevated salt concentrations in the…

skin diseses

Skin Diseases May Be More Prevalent Than Previously Thought

Dermatologic diseases are the fourth most common cause of all human illnesses, with approximately one‐third of the world’s population being affected by at least one skin condition. There are more than 3000 skin diseases that vary in severity and symptoms, from self‐limiting infections and benign tumours, to chronic inflammatory diseases and malignant neoplasms that cause…

skin repair

Skin Repair Eliminates 'Inflammaging' Linked Chronic Disease

Skin is the body’s largest organ, and scientists at UC San Francisco and the San Francisco Veterans Administration (VA) Health Care System think it may be to blame for body wide inflammation linked to numerous chronic diseases of aging. The good news is that properly caring for the skin with a moisturizing cream may lower…

Eczema

FDA OKs Dupilumab for Moderate-to-Severe Eczema in Teens

The US Food and Drug Administration (FDA) has approved dupilumab (Dupixent, Sanofi/Regeneron) for adolescents aged 12 to 17 years with moderate-to-severe atopic dermatitis poorly controlled with topical prescription therapies or when those therapies are not advisable. Dupixent can be used with or without topical corticosteroids. Dupilumab is a targeted biologic therapy that inhibits interleukin-4 and interleukin-13; but…

Skin aging

Improvement Of Skin Viscoelasticity And Density

Skin aging is a characteristic that causing many concerns in the present population; with different types of treatments being developing. It can characterize by a progressing process of drying; changes on the skin microrelief, loss of firmness, and elasticity that results on wrinkles and sagging. The combination of oral supplementation and topical formulations; to the…

Skin cancer

Common Skin Cancers Among Patients With Skin of Color Identified

The objective of the study was to update the epidemiology, investigate specific risk factors; and facilitate earlier diagnosis and intervention of KC in nonwhite individuals. IRB-approved retrospective chart review of all non-white individuals who had received a biopsy-proven diagnosis of skin cancer at Drexel Dermatology from June 2008 to June 2015. The need for photoprotection…

Butterfly Disease

Potential Treatment For Cancer In Butterfly Disease

Children with the severe skin disease, recessive dystrophic epidermolysis bullosa (RDEB), also known as butterfly disease, often develop an aggressive and fatal skin cancer by early adulthood. Now an international team of scientists have identified a potential drug treatment for the lethal complication. The discovery paves the way for a clinical trial set to begin…

Skin Malignancies

Childhood Cancer Survivors at High Risk for Skin Malignancies

As adults, childhood cancer survivors have a 30-fold higher risk than the general population;  but of developing basal cell carcinoma, a Dutch study suggests. Compared to other adults, survivors had a more than two-fold higher risk of getting melanoma – the most aggressive and deadly type of skin cancer and a more than seven-fold risk…