Psoriasis appears to be significantly associated with inflammatory bowel disease (IBD). The study was published in JAMA Dermatology. Researchers assessed case-control, cross-sectional, or cohort studies that examined either the odds or risk for IBD in patients with psoriasis.
Based on five case-control or cross-sectional studies and four cohort studies that involved a total of 7,794,087 participants, the authors found significant associations between psoriasis and Crohn's disease (odds ratio, 1.7) and between psoriasis and ulcerative colitis (OR, 1.75).
In addition, patients with psoriasis had an increased risk for Crohn's disease (risk ratio, 2.53) and ulcerative colitis (risk ratio, 1.71).
Patients with psoriasis may experience comorbidities involving cardiovascular diseases, chronic kidney disease, uveitis, psychiatric disturbances, and metabolic syndrome. However, the association between psoriasis and inflammatory bowel disease (IBD) has been largely unclear.
Gastroenterology consultation may be indicated when patients with psoriasis present with bowel symptoms. These findings suggest that psoriasis is significantly associated with IBD.