Acne inversa is associated with an elevated risk for stroke, coronary artery disease, heart failure, and peripheral artery disease, according to a new study. And this risk persists even after they control for comorbidities such as hyperlipidemia, smoking, and diabetes,” said lead investigator Rachael Ward, MPH, from Duke University School of Medicine in Durham, North Carolina.
Hidradenitis suppurativa (HS), also known as acne inversa, is a long term skin disease characterized by the occurrence of inflamed and swollen lumps.These are typically painful and break open releasing fluid or pus. The areas most commonly affected are the underarms, under the breasts, and groin. Scar tissue remains after healing. Self-consciousness or depression may result.
Genetic and environmental factors
The exact cause is usually unclear but believe to involve a combination of genetic and environmental factors. About a third of people with the disease have an affected family member. Other risk factors include obesity and smoking.The condition is not infectious, related to hygiene, or to the use of deodorant. The underlying mechanism is believed to involve either a dysfunction of apocrine sweat glands or hair follicles. Diagnosis is based on the symptoms.
When these patients present to dermatologists or to primary care physicians or even pediatricians; so because acne inversa can occur in kids they should be screening them much more vigilantly so that they can identify cardiovascular disease risk factors. If they have diabetes, they need to start them on treatment right away.
If they have hyperlipidemia, refer them to start on appropriate treatment or refer them to a healthy lifestyle clinic where they can learn about healthy diet and exercise. These patients have a higher comorbidity burden than the general dermatology patients they see on a regular basis; said senior study investigator Tarannum Jaleel, MD, also from Duke, who presented the findings at the American Academy of Dermatology 2019 Annual Meeting in Washington, DC.
Primary care physician
Many do not have a primary care physician. They treating a lot of patients aged 17, 18; who had BMIs close to 40 kg/m². They were presenting with dyslipidemia at a much younger age than you would expect reported. Jaleel explained that she now screens these patients; even though they may be young because they get their heart attacks much younger than people who don’t have acne inversa.
Ward prompt to examine the link between this skin condition and cardiovascular disease; so because many of her family members who had acne inversa died early from heart disease. After a literature search failed to provide conclusive evidence of a link; so she and her colleagues decided to conduct their own population-based analysis.
The team performed a retrospective cohort study of 4914 patients at Duke University Medical Center with an ICD code for hidradenitis suppurativa; so 4641 patients with an ICD code for psoriasis, and a random selection of 23,266 healthy control subjects.