Left ventricular assist devices, or LVADs, have been shown to help leaky mitral valves that create significant regurgitation, but a new study questions the presumption that all’s well with the mitral valve after a patient receives a LVAD. The study, published in The Journal of Thoracic and Cardiovascular Surgery, finds that when people with advanced heart failure have residual mitral regurgitation after their mechanical pump is placed, it can negatively affect right heart function, too.
This is because the back pressure from the leaky mitral valve increases pressure in the veins; which leads from the lungs to the heart, resulting in a fluid build-up that imposes more work for the right side of the heart; says lead author Paul Tang, M.D., Ph.D., a cardiac surgeon at Michigan Medicine’s Frankel Cardiovascular Center. Mitral valve procedures are not perform; so because of the standing belief that LVAD support resolves mitral regurgitation, due to better left heart performance.
Severity of mitral valves
The idea that LVAD implantation decreases the severity of leaky valves has support in prior studies; also at a significant proportion. However, according to Tang, studies which claim; so that severe backflow before LVAD implantation doesn’t affect clinical outcomes haven’t specifically examined patients with poor right heart function. Tang says his study might surprise some providers; but that’s why it’s so important.
Tang and colleagues identified 159 patients with severe mitral regurgitation; so before surgery who underwent an LVAD implantation between 2003 and 2017. The results suggested residual; persistent mitral regurgitation after LVAD implantation leads to higher pulmonary vascular resistance and contributes to poor right heart function; persistent pulmonary hypertension and increased readmissions later on. Poor postoperative function in the right heart can; which subsequently lead to heart failure and worse survival rates.
The study had three groups, with varying severity of mitral valve leakage and right heart dysfunction. The group of patients with the most severe dysfunction in both the mitral valve and the right heart were more likely to have the longest hospital stay. More than half needed a tricuspid valve procedure. Tricuspid regurgitation occurs in the same way mitral regurgitation does a leaky valve causes blood to leak back and create pressure on the heart.
Worse right heart function
“You cannot study the mitral valve in isolation and get the whole picture,” says Tang. “It’s a downstream valve; so it can affect many different upstream pieces of the puzzle.” Tang and colleagues determined that more mitral regurgitation; also worse right heart function before an LVAD implantation increased a patient’s risk of right heart failure due to the residual leaky valve that may only be fixed with a mitral valve repair.
“Researcher find that if the patient’s regurgitation didn’t get better; but they had a strong right heart function; the heart could overcome the pressure from regurgitation to retain good outcomes,” says Tang. Tang and colleagues say patients like those in the group with a more severe leaky valve or right heart dysfunction prior to an LVAD implantation could benefit; so the most from restoring mitral valve competency with repair since they’re most likely to have residual mitral regurgitation and worse right heart function.
“Only recently have issues with the mitral valve been challenged in regard to mitral valve regurgitation,” says Dr. Tang. “They need to look aggressively about addressing mitral regurgitation particularly in patients who are not transplant candidates and will live with the LVAD long term.” He adds that future randomize clinical trials are critically need to definitively determine; whether a subset of patients would benefit from mitral valve repair.