Systolic Blood Pressure; The cumulative effect of elevated systolic blood pressure appears to be associated with an increased risk for major valvular heart disease, according to a study published online July 10 in JAMA Cardiology. Milad Nazarzadeh, from the University of Oxford in the United Kingdom, and colleagues evaluate data from the U.K. Biobank (502,602 men and women aged 40 to 96 years at baseline between 2006 and 2010) using Mendelian randomization to examine the association between systolic blood pressure and major valvular heart disease.
Genetic effect of high BP
Isolate systolic hypertension can be cause by underlying conditions such as artery stiffness; so an overactive thyroid (hyperthyroidism) or diabetes. Occasionally, it can be cause by heart valve problems. It is the most common form of high blood pressure in people older than age 65, but it is possible for younger people to be affect by this type of high blood pressure as well. Doctors now know that high systolic pressure is as important as high diastolic pressure and even more important in people older than age 50. Having a high systolic pressure for a long period of time can increase your risk of having significant cardiovascular problems, such as a heart attack or stroke.
Systolic BP was measure during clinical assessment and instruments for the genetic effect of high BP were identify from variants that were independently (linkage disequilibrium threshold of r2<0.1) associate with systolic BP with minor allele frequency greater than 0.01. A total of 130 single-nucleotide polymorphisms that have been shown to be associate with systolic BP in a genome-wide association meta-analysis involving 1 million participants of European ancestry were selected.
Systolic Blood Pressure
Incident aortic stenosis, aortic regurgitation, and mitral regurgitation, individually and combined. Cases were largely base on hospital records link to the UK Biobank; with International Classification of Diseases and Health Relate Problems, Tenth Revision codes. The final analysis include 329,237 participants (53.99% female; mean age, 56.93 years) with valid genetic data and blood pressure measurements.
Among this cohort, the authors report that 3,570 individuals (1.08%) had a diagnosis of valvular heart disease (aortic stenosis, 0.45%; aortic regurgitation, 0.19%; and mitral regurgitation, 0.53%). For each genetically 20-mm Hg increment in systolic blood pressure; so there was an increase risk for aortic stenosis (odds ratio [OR], 3.26; 95% confidence interval [CI], 1.50 to 7.10); aortic regurgitation (OR, 2.59; 95% CI, 0.75 to 8.92), and mitral regurgitation.
There was no evidence for heterogeneity by type of valvular heart disease (P = 0.90). Associations remain robust in sensitivity analyses. “Lifetime exposure to elevate systolic blood pressure may be associate with an increase risk of major valvular heart disease; so suggesting that blood pressure lowering might be a useful strategy for prevention of this condition,” the authors write.