During a heart attack, the supply of oxygen to heart cells is decreased. This reduced oxygen level, called hypoxia, causes the cell's powerhouses, the mitochondria, to fragment, impairing cell function and leading to heart failure. Until now, few details have been known about how this process occurs
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Atherosclerotic disease, the slow and silent hardening, and narrowing of the arteries is a leading cause of mortality worldwide. It is responsible for more than 15 million deaths each year, including an estimated 610,000 people in the United States
Mice with heart failure that were treated with AAV8-based gene therapy to deliver the protein urocortin 3 (UCn3) had increased blood levels of UCN3 over a 5-week period and improved heart function. The mice received a single injection of AAV8.UCn3 after cryoinjury to induce left ventricular heart failure and showed significant improvements in both systolic and diastolic heart function, as reported in an article published in Human Gene Therapy
A South American tribe living in near-total isolation with no Western dietary influences showed no increase in average blood pressure from age one to age 60, according to a study led by Johns Hopkins Bloomberg School of Public Health. In comparison, a nearby tribe whose diet includes some processed foods and salt did show higher blood pressure into late middle age
Heart attacks once characterized as a part of "old man's disease" -are increasingly occurring in younger people, especially women, according to new research. The study, presented Sunday at the American Heart Association's Scientific Sessions meeting in Chicago and published in the AHA journal Circulation, sought to investigate heart attacks in the young, a group frequently overlooked in cardiovascular research
In a clinical trial involving 18,924 patients from 57 countries who had suffered a recent heart attack or threatened heart attack, researchers at the University of Colorado Anschutz Medical Campus and fellow scientists around the world have found that the cholesterol-lowering drug alirocumab reduced the chance of having additional heart problems or stroke
Researchers have developed a way to grow human heart tissue that can serve as a model for the upper chambers of the heart, known as the atria. The tissue, derived from human induced pluripotent stem cells (hiPCSs), beats, expresses genes and responds to drugs in a similar manner to a real human atrium
A drug therapy used for patients with chronic heart failure also improves markers of poor prognosis in individuals who are hospitalized with acute heart failure, new Yale-led research shows. The findings suggest that the drug can improve outcomes for acutely ill heart patients and potentially become the new standard of care for treating this serious condition, the researchers said.
Cardiac muscle degeneration cardiomyopathy is the most common cause of severe cardiac dysfunction and life-threatening cardiac arrhythmias in children. These severe disorders often lead to consideration of heart transplant. However, their actual cause the genetic basis, that is has been poorly characterized.
High blood levels of troponin, a protein released by injured heart muscle, can tell if someone recently experienced a heart attack. Measuring lower, but still problematic, levels of troponin can provide useful long-term information for cardiologists. The study was published in Annals of Internal Medicine.
Accumulations of low levels of lead in the shin bone of men were associated with treatment-resistant high blood pressure. The study was published in the Journal of the American Heart Association, the Open Access Journal of the American Heart Association/American Stroke Association.
Sudden cardiac death is a common cause of death in patients with congenital or acquired heart disease. An implanted cardiac defibrillator (ICD) can effectively put a stop to any underlying cardiac arrhythmia. In a long-term observational study involving 1,500 patients.
Researchers have shown that the progress selected for the implanted defibrillators (ICDs) plays a major role. It was found that the most "defensive" possible procedure is safe and, at the same time, significantly reduces inappropriate therapy.
The study was published in Circulation.