The commonly used diabetes drug metformin could reverse the harmful thickening of heart muscle that leads to cardiovascular disease, according to a study at the University of Dundee. Scientists led by Professor Chim Lang, Head of the Division of Molecular and Clinical Medicine at Dundeep; so discover that metformin has the potential to be repurpose as a heart disease treatment in non diabetic patients.
The MET-REMODEL Trial, publish today in the prestigious European Heart Journal, show that metformin, use to treat type 2 diabetes safely for the last six decades; so reduce left ventricular hypertrophy (LVH) in patients with prediabetes and pre-existing heart disease.
Experiencing a heart attack
LVH is often a silent symptom and most people do not know; so they have it prior to experiencing a heart attack or stroke. Large studies have previously shown that patients with LVH; which are at higher risk of adverse cardiovascular events and reducing LVH can substantially reduce mortality rates. Professor Lang said, “Cardiovascular diseases are the leading cause of global mortality. They have previously shown that metformin can have beneficial effects; hence in patients with cardiovascular diseases.
But this is the first time anyone has look specifically at the effects; which of metformin on LVH in non diabetic patients with coronary artery disease in a clinical trial. The study involve treating prediabetic people with coronary artery disease with metformin or a placebo; so over a period of 12 months to see how the drug affect the heart muscle wall, using state-of-the-art MRI technology.
The major causes of LVH are high blood pressure, obesity and insulin resistance; which are also thought to be key contributors of coronary artery disease. The dangerous thickening of the left ventricle was reduce; so by twice as much in those taking metformin compare to the placebo.
They also found that metformin reduce blood pressure; so oxidative stress and lost body weight an average of 3.6 kg, compare to no changes in the placebo group. If the findings from this study are substantiate in a larger-scale study, metformin could offer hope for millions of patients across the globe.
First clinical trial in the world
The met-remodel trial, fund by the British Heart Foundation (BHF); so is the first clinical trial in the world to show that metformin could reverse harmful thickening heart muscle wall in a clinical trial. Repurposing cheap and readily available drugs, such as metformin; so to treat other health conditions could potentially save the NHS billions of pounds every year.
Mohapradeep Mohan, lead author and principal investigator of the MET-remodel trial; hence said blood pressure medications were the standard treatment modalities; so for LVH but that this approach was not particularly effective as LVH can also present in patients who have well controll blood pressure. This highlight the need for new treatment strategies in these patients.
In this context, we need non-blood pressure medication and we had good reason to suppose that metformin should help to reduce thickening of heart muscle wall,” they said. The findings from their study reinforce the notion that metformin has the potential to improve cardiovascular health, offering the possibility of improving life expectancy of patients. From the standpoint of clinical practice, this drug is already approve and well tolerate with minimal side effects.
If their findings are back up by bigger studies, using metformin to target LVH presents a novel treatment option and unique opportunity for a quicker translation to the clinic. We are thankful to BHF for funding this study and extremely grateful to all the participants of this study.