Nanoparticles Are Using To Deliver Drugs Into The Cell

As insight is important if nanoparticles are to be using to deliver drugs into the cell. The experimental framework using here does not allow; for any long-term statements to be made regarding any increasing probability of cell mutation resulting in cancer. Carbon nanoparticles are a promising tool for biomedical applications, for example, for targeted transportation of biologically active compounds into cells.

Biological risk potential of nanoparticles studying in the research; whether these particles are potentially dangerous for the organism and how cells cope with them once they have been incorporating. Nanoparticles are smaller than five nanometres a nanometre being one millionth of a millimetre which corresponds approximately to the size of macromolecules. Such tiny particles are very easily absorbed in body cells.

There are two aspects to this feature. On the other hand, they can also pose health risks; for example in connection with particulate matter. One of the ways that particulate matter is created is in combustion processes, and part of that can be classified as nanoparticles. These extremely small particles can overcome the blood air barrier and penetrate the body.

Nanoparticles drugs deliver

The bronchial mucosa in the lungs doesn’t filter out the particles. Instead, they make their way into the pulmonary alveoli and from there into the bloodstream. The researchers used nanoparticles made from graphene; this is a special form of carbon that comprises two-dimensional layers of hexagonal carbon rings. They added these to special haematopoietic stem cells referred to as CD34+ stem cells.

These cells are particularly sensitive to damaging environmental influences on account of their ability to divide throughout their lifespan. The assumption is that these cells would be damaging more by nanoparticles if at all than the more robust other cell types. The interdisciplinary team of researchers based in Düsseldorf was able to demonstrate that the carbon nanoparticles get into the cells; where they are encapsulating in special organelles called lysosomes.

Genes of stem cells

The lysosomes serve as a type of waste removal unit; for the body where foreign bodies accumulate and are normally breaking down with the help of enzymes. However, the researchers didn’t observe any such process over the duration of the experiments, which lasted for several days. When comparing the active genes of stem cells with and without the addition of nanoparticles.

But the researchers finding that only one of a total of 20,800 recording expressions had changed; minor effects were determining in a further 1,171 gene expressions. Encapsulation of the nanoparticles in the lysosomes ensures; that these particles are storing securely at least for a few days for the duration of our experiments and cannot damage the cell. This means the cell remains viable without any major change in gene expression