This research showing that ammonia assisted hot water etching strategy ;for the generic synthesis of a library of small-sized (sub-50 nm) hollow mesoporous organosilica nanoparticles (HMONs); with mono, double, triple; and even quadruple framework hybridization of diverse organic moieties by changing only the introduced bissilylated organosilica precursors.
But in this method research showing nanoparticle is carrying a different class of molecules compounds; designed to work with radiation and enhance its ability to kill tumor cells.The nanoparticle ;that they engineered is known a hollow mesoporous organosilica nanoparticle (HMON); Mesoporous refers to the size of the pores in the nanoparticle, through which anti-cancer compounds can be loaded and then released when they reach the tumor.
A mesoporous material contains pores with a diameter between 2 and 50 nanometers. By using ammonia assisted hot water etching to engineer very small nanoparticles. Creating very small nanoparticles was important because the smaller particles could travel to the center of the tumor; which was the primary to this study.
But some temporary appearance of solid like nanoparticles owing to the dissolved products that might enter and fill the cavity of some non-degraded HMONs; or re-generate some silica nanoparticles; the whole HMONs could be gradually degrading with the increasing time of incubation in GSH solution; Especially, the hollow-structured thioether-hybridized HMON exhibited a large surface area of 426 m2 g−1 and uniform mesopore sizes of 3–6 nm, allowing for sufficient encapsulation of diverse hydrophilic/hydrophobic payloads.
The loaded nanoparticles testing in a human glioblastoma cell line;for the amount of DNA damage that generating when combined with radiation; A test that dyes the DNA fluorescent red clearly showed that the combination of the nanoparticles and radiation shredded the DNA of the glioblastoma cells compared with nanoparticles alone or radiation alone.However, when the nanoparticle was injected and then activated by radiation; the tumors shrank dramatically with no toxic effects on the organs of the mouse.
During the process, the amount of triethanolamine (TEA) was the key parameter to control the particle size below 50 nm;Based on this, an ammonia assisted hot water etching strategy developing to fabricate sub-50 nm HMONs by selectively etching away the MSN core while leaving the intact MON shell;The internal cavity of the sub-50 nm HMONs enabled substantial encapsulation of various kinds of drugs and other bio molecules.