All news from Bio-Chemistry

antiviral protein RIG-I

mRNA: Inhibits Immune Functions of Antiviral Protein

Hepatitis C virus (HCV) is a hepatotropic virus, with about 80 million chronic infections confirmed worldwide. HCV infection leads to the development of chronic hepatitis, cirrhosis, and in some instances, hepatocellular carcinoma. The recent development of highly potent direct-acting antiviral drugs (DAAs), targeting viral proteins, facilitates virus elimination in >90 percent of treated individuals. However,…

Obesity

Researchers Relate DNA Methylation Levels to Obesity

Metabolic syndrome (MetS) has postulated to increase the risk for type 2 diabetes, cardiovascular disease and cancer. Adipose tissue (AT) plays an important role in metabolic homeostasis, and AT dysfunction has an active role in metabolic diseases. MetS is closely related to lifestyle and environmental factors. Epigenetics has emerged as an interesting landscape to evaluate…

Obesity

Keep People From Gaining More Weight

During a plane ride, Sara Bleich watched a flight attendant take an overweight passenger’s drink order. The passenger asked for cranberry juice. “Cranberry juice is our highest-sugar beverage on the menu,” the flight attendant said. “Would you like a diet beverage?” “Just give me the cranberry juice,” the passenger said. As a public policy expert…

'Electron shuttle' protein

'Electron Shuttle' Protein: Key Role in Plant Cell-wall Construction

Scientists studying plant cell walls; structural supports that help plants overcome the downward pull of gravity; have discovered mechanistic details of a protein; involved in the assembly of lignin; a key cell-wall component. Firstly, the protein acts as a targeted “electron shuttle;” delivering the “fuel” that drives; the construction of one specific type of lignin…

Unexpected connection

Insulin Receptor and Gene Expression: Insulin-related Disease Research

The discovery of insulin in the 1920s; marked the breakthrough in the almost 3,500-year-long mystery of diabetes; a disease first described in ancient Egyptian papyruses. Until its discovery, physicians struggled to explain; how symptoms such as sugary urine, constant thirst and frequent urination; could lead to ailments ranging from blindness; and nerve damage to coma…

First case of person without the protein

The Protein Needed to Transport Vitamin D

Research identifying the first case of a person living without the protein needed to bind and transport vitamin D in the bloodstream has been published in the New England Journal of Medicine. The paper, led by a University of Calgary geneticist; and co-authored by researchers at the University of Washington in Seattle; U.S., and University of…

nerve diseases

Protein Key to Charcot-marie-tooth, Other Nerve Diseases

A new study provides critical insight into a little-known, yet relatively common, inherited neurological condition called Charcot-Marie-Tooth disease. The findings point to a pathway to possible treatments for this disease; and better understanding of other neurodegenerative disorders; including Alzheimer’s disease, that affect millions. The study focused on two related proteins, MFN2 and MFN1; found on…

Anti-inflammatory

Anti-inflammatory Plant-based Diet: Helps Reduce Gingivitis

Periodontal disease is one of the most prevalent inflammatory diseases of mankind; and estimated to affect about 732 million people worldwide; with an increasing incidence. It is; considered to be the main cause for tooth extractions; in Germany. Gingivitis as a necessary pre‐requisite for periodontal disease; is even more prevalent and a main risk factor…

Metabolism

Reviewing Low-carb, Other Diets for Guidelines

With keto-friendly recipes sweeping social media, some followers of low-carb eating; are hoping for a nod of approval in the upcoming U.S. dietary guidelines; that advise Americans on what to eat. It may seem minor, but backers say low-carb’s inclusion; could influence nutrition advice; that doctors give and help shape government food programs; like school…

Obesity

Biological Mechanisms Behind Obesity-cancer Link

New studies led by University of North Carolina Lineberger Comprehensive Cancer Center; researchers explore biological mechanisms behind obesity; and its link with cancer. Research findings presented at the American Association for Cancer Research Annual Meeting 2019; explore possible reasons for obesity-related resistance; to breast cancer treatment and possible strategies to overcome obesity-related immune suppression in…

Biochemistry

Vitamin C Can Reduce The Length of ICU Stay

Vitamin C administration shortened the length of stay in the intensive care unit on average by 8% in 12 trials with 1766 patients according to a meta-analysis published in Nutrients. The biochemistry of vitamin C is complex. For example, it is involved in the synthesis of norepinephrine and vasopressin, both of which influence the cardiovascular…

keto diet

Just One Dose of Glucose: Damage Blood Vessels

The often embraced ‘cheat day’ is a common theme in many diets and the popular ketogenic diet is no exception. But new research from UBC’s Okanagan campus says; that just one 75-gram dose of glucose; the equivalent a large bottle of soda or a plate of fries; while on a high fat, low carbohydrate diet…