All news from Bio-Chemistry

Pathogenic Pathway Linking A Lysosomal Deficiency

Pathogenic Pathway Linking A Lysosomal Deficiency

Lysosomal exocytosis is a ubiquitous process negatively regulating by neuraminidase; a sialidase mutating in the glycoprotein storage disease sialidosis. Mutations in the NEU1 gene cause the lysosomal storage disease sialidosis, which belongs to a large group of related pediatric diseases. The study discovering an association between a deficiency in the enzyme neuraminidase 1 (NEU1); and…

Enzymes Showing Action In Gene-editing

Enzymes Showing Action In Gene-editing

CRISPR, short for CRISPR-Cas9, is a gene-editing tool in which the enzyme Cas9 acts like a pair of molecular scissors, capable of cutting strands of DNA. Once the enzyme makes cuts in DNA at specific sites, insertions and edits can be made, therefore changing the DNA sequence. The images captured using a technique called cryogenic…

Glycogen Branching Enzymes Potential Role In Glycogen Biosynthesis

Glycogen Branching Enzymes Potential Role In Glycogen Biosynthesis

The glycogen is a highly branching α-glucan polymer widely using as energy and carbon; reserve by many microorganisms. Where the most of microorganisms have typically only a single glycogen branching enzyme (gbe) gene. But few microorganisms carry both the GH13 and GH57 gbe genes; such as the Petrotoga mobilis and Mycobacterium tuberculosis. Here we report the basic…

Metabolic Enzymes Tied To Fatty Liver Disease

Metabolic Enzymes Tied To Fatty Liver Disease

The researchers conducted the study, to determine if the exposure to specific chemicals enhances obesity. Specifically, they wanted to identify the role of Cyp2b in unsaturated fatty acid metabolism enzymes, regardless of diet. Some chemicals could inhibit the gene, an event shown in the experiment with Cyp2b-null mice. The research study team using a laboratory…

Proteins Play Central Roles In The Proper Folding And Oligomerization

Proteins Play Central Roles In The Proper Folding And Oligomerization

Proteins are large biomolecules, or macromolecules; consisting of one or more long chains of amino acid residues. Specific interactions between the helical membrane-spanning domains of transmembrane proteins; play central roles in the proper folding and oligomerization of these proteins. But proteins perform a vast array of functions within organisms, including catalysing metabolic reactions. These proteins…

Protein Tau Has Extensive Structure

Protein Tau Has Extensive Structure

The tau protein, which binds to microtubules and promotes microtubule assembly and stability; is encoding by the microtubule associating protein tau (MAPT) gene on chromosome. The MAPT gene is well conserving; with 97 to 100% homology among primates. This 134 kb gene is comprising of 16 exons; among which exons and 10 are knowing to…

Essential Protein For Correct Heart Contraction

Essential Protein For Correct Heart Contraction

The study identifying the RNA-binding protein SRSF3 as an essential factor; for proper heart contraction and survival. But finding that the loss of cardiac expression of SRSF3 leading to a critical reduction; in the expression of genes involve in contraction. Study of the mechanism of action of SRSF3 in the heart could open the way…

Visual Discrimination Of Proteins And Microorganisms

Visual Discrimination Of Proteins And Microorganisms

Gold nanoparticles basing colorimetric array methods; are gaining increasing attention in the discrimination of biomacro molecules and microorganisms. Single-stranded DNA has been demonstrating a powerful recognition element for proteins discrimination with AuNP-based colorimetric array method due to the diversity of DNA base sequence. Amino acid can interact with AuNPs through amino groups via the electrostatic…

Labeling Of The Peptides And Proteins

Labeling Of The Peptides And Proteins

Proteins are macromolecules constructing; from a set of twenty chemically different amino acids. One key approach to modifying proteins and peptides is to reacting with the sulfur atom in the amino acid cysteine. Understanding the structure and metabolism of cells and living organisms; is essential for the development of new drugs and diagnostics. The method…

Salinity Of Water Affects Calcium Carbonate Nucleation

Salinity Of Water Affects Calcium Carbonate Nucleation

The concentration of salt in water varies widely; seawater has about 35 grams of salt per liter; while water used in hydraulic fracturing containing even higher concentrations of salts. But the formation of calcium carbonate (CaCO3) in water has ramifications for everything from food; and energy production to human health; and the availability of drinkable…

Muscle Building Stimulating Protein To A Greater Extent Than Milk Protein

Muscle Building Stimulating Protein To A Greater Extent Than Milk Protein

A mycoprotein can stimulate muscles; to grow faster in the hours following exercise comparing with a typical animal ;comparator protein (milk protein); But study looking forward to seeing whether these mechanistic; findings translate to longer term training studies in various populations. The young men performed the exercise and were then given either milk protein or…

Protein Linked Sugars Are Crucial For The Uptake Of Proteins

Protein Linked Sugars Are Crucial For The Uptake Of Proteins

Parkinson’s disease, a neurodegenerative disorder that affecting more than 6 million people worldwide; is causing by the buildup of alpha-synuclein protein in the brain. This research focusing on the acetylating form of alpha synuclein proteins; which is present in both healthy and diseasing neurons and is less frequently studying. But the study that the acetylating…