All news from Bio-Chemistry

Delicate Balance Of The Microbiome Resulting In Permanent Damages

Delicate Balance Of The Microbiome Resulting In Permanent Damages

As the multi-resistant germs becoming more and more of a threat; this are in need of new antibiotics now more than ever. Unfortunately, antibiotics cannot distinguish between pathogens; and beneficial microbes. They can destroy the delicate balance of the microbiome resulting in permanent damages. The researchers discovering antibiotic properties of a natural product; that so…

Hot Spots On The Surface Of Bacteria's Critical Enzyme

Hot Spots On The Surface Of Bacteria’s Critical Enzyme

The study revealing the undiscovering hot spots on the surface of bacteria’s critical enzyme; which could guide novel approaches to antibiotic design. As a novel antibacterial agents are needing to address the emergence of the global antibiotic resistance. Researchers have identified key sections of a bacterial enzyme that could be targeting with the new drugs to…

Benefits Of Calorie Restriction On Human Lifespan

Benefits Of Calorie Restriction On Human Lifespan

As calories are the unit of energy; which it requiring by all the organs in the body. By calorie restricting diets have been shown to increase the lifespan and healthspan. But as long as there is no malnutrition; and while no long-term studies have proving the benefits of calorie restriction on human lifespan; shorter-term studies…

Crystal Structure Of The Enzyme That Making Antibiotic Agent

Enzymes Making Broad Spectrum Antibiotic Agent

As enzymes are the biological catalysts; that initiating chemical reactions. By using X-ray crystal structure of the enzyme that making obafluorin a broad spectrum antibiotic agent made by a fluorescent strain of soil bacteria. A multi-part enzyme knowing as an nonribosomal peptide synthetase produces the highly reactive beta-lactone ring that is responsible for obafluorin’s antimicrobial…

Therapeutic Strategies To Combat Cancers Caused By HMGA1a

Therapeutic Strategies To Combat Cancers Caused By HMGA1a

The protein HMGA1a adopts dynamic, more compact structures that depend on its phosphorylation. A malfunction of HMGA1a can lead to cancer. The researchers considering therefore expect their results to form a basis for future therapeutic strategies to combat cancers caused by HMGA1a. While the correct function of many proteins depends on their three-dimensional structure, some…

Silk Glands Predicts Proteins Contributing To Dragline Silk

Silk Glands Predicts Proteins Contributing To Dragline Silk

The study finding an new proteins in the strongest spider web material; Spider silks are the toughest biological materials in nature due to combined strength and extensibility, leading to enormous interest in engineering silk-based biomaterials for industrial applications. Humans have been impressed by the silkmade from spiders for thousands of years. Due to this impression…

The Nature Builds Hydrogen Producing Enzymes

The Nature Builds Hydrogen Producing Enzymes

The study on the hydrogen-producing enzymes; called hydrogenases, are activating during their biosynthesis. As they showing how the cofactor part of the active centre; and also the heart of the enzyme is introducing inside. The maturation of each hydrogenase class describes the process that converts an apo-hydrogenase into an active holoenzyme involving a machinery of…

Protein Switch Allows Unprecedented Control Over Living Cells

Protein Switch Allows Unprecedented Control Over Living Cells

A new study regarding the artificial protein switch; that can work inside living cells to modify or even commandeer the cell’s complex internal circuitry. The switch is dubbing LOCKR; short for Latching, Orthogonal Cage/Key pRotein. Studying LOCKR’s design and demonstrate several practical applications of the technology. The study showing that LOCKR can be programming to…

Mechanism For The Deactivation Of Switch Proteins

Mechanism For The Deactivation Of Switch Proteins

Researchers identifying a new mechanism for the deactivation of switch proteins, Switch proteins such as Ras regulate many processes in the body and affect diseases such as cancer. Bound to switch proteins, the GTP molecule is vital for the deactivation of many of them. If one of the three phosphate groups is detaching from GTP,…

Small Molecule Inhibitors Of CRISPR-Cas9

Small Molecule Inhibitors Of CRISPR-Cas9

A new platform efficiently identifies small molecule inhibitors; that allow control of CRISPR-Cas9 activity in genome engineering technologies. Several applications of CRISPR enzymes (therapeutic or otherwise) can benefit from control of their activity over the dimensions of dose and time. In contrast to protein based inhibitors for CRISPR systems found in viruses, the newly identified…

Organic Molecule As Potent Weapon Against Antibiotic resistance

Organic Molecule As Potent Weapon Against Antibiotic resistance

A new innovative study on the organic molecule composed; of simple sugars could become a potent weapon in the fight against rising antibiotic resistance; according to EU-funded researchers who have developed a novel; targeted drug-delivery technique to treat deadly tuberculosis and other lethal pathogens. By targeting tuberculosis, one of the leading causes of death worldwide…

Lipophilization Based On Enzyme Retention

Lipophilization Based On Enzyme Retention

As anthocyanin lipophilization emerged as an efficient technique to improve their enzyme chemical stability; liposolubility and antioxidant properties for novel technological applications. Protein extract, rich in lipase B, in powder form from Candida antarctica was kindly donating by Genofocus. Enzyme retention in the membrane is due to enzyme adsorption at the pore walls of the…