All news from Bio-Chemistry

Role of Proteins to Break up Energy Structures in Oxygen Starved Heart Cells

Researchers found that the filamin A-Drp1 complex mediates mitochondrial fission in a mouse model of hypoxic heart cells. Results show that hypoxic stress brought about the interaction of filamin A with Drp1 and increased Drp1 activity in heart cells. This process led to mitochondrial fragmentation and cell senescence. Further investigation demonstrated that the drug cilnidipine suppressed Drp1-filamin A complex formation and preserved heart cell function.

Lipids and Cell Membranes in our Bodies Affect Aging, Long-term Health, Study

A professor at Worcester Polytechnic Institute (WPI) is examining aging on the molecular level, examining how the lipids found in our bodies, particularly those in our cell membranes, change as we age, and how those changes may affect bone and muscle strength, brain health, and our propensity for age-related diseases, including Alzheimer's disease. With a two-year, nearly $ 421,000 grant from the National Institutes of Health, Carissa Perez Olsen hopes to gain a better understanding of the role of lipids play in longevity and long-term health.

Differences Between Nucleosides And Nucleotides

The difference between nucleosides vs. nucleotides involves the presence or absence of a phosphate group. A nucleoside consists of a nucleobase and a sugar (ribose or deoxyribose) whereas a nucleotide contains a nucleobase, a sugar, and one or several phosphate groups. Hence, the main difference is nucleotides have phosphate groups and nucleosides do not.

Ribbon Shaped Molecules Represent Protein Structure

A correspondent sent along this item, celebrating the inventor of something that’s so ubiquitous in molecular biology and protein chemistry that you have to think for a moment to realize that it had an inventor: the ribbon diagram. That’s Jane Richardson of Duke, who started there in 1969, back when there were only about 20 entries in what was not yet the PDB because that hadn’t been invented yet, either.

Mechanisms Of Heat-Resistant Enzymes For Drugs

A recent study looked at one of the most essential enzymes in medicine to aid better, and more cost-effective design of drugs. The mechanisms and actions of heat-resistant enzymes are being investigated to aid better, more cost-effective drug design. 

The research was co-authored by Dr. Nitin Jain, UT Biochemistry and Cellular and Molecular Biology Associate Professor, and graduate student Sara Lemmonds. It is focused on Cytochrome P450, an enzyme that occurs naturally in the body and other environments, and one that is critical in metabolizing over 90% of pharmaceutical drugs.

The study was published in the Proceedings of the National Academy of Sciences.

New Insight Into Enzyme Evolution

The brilliant physicist Richard Feynman famously said that, in principle, biology can be explained by understanding the wiggling and jiggling of atoms. A new research explains how this 'wiggling and jiggling' of the atoms in enzymes the proteins that make biological reactions happen is 'choreographed' to make them work at a particular temperature.

Enzyme catalysis is essential to life, and this research is based on how enzymes have evolved and adapted, enabling organisms to evolve to live at different temperatures.