Researchers from Charité — Universitätsmedizin Berlin have been able to demonstrate how, on a molecular level, a specific protein allows light signals to be converted into cellular information. Their findings have broadened our understanding of the way how plants and bacteria adapt to changes in light conditions, which regulate essential processes, such as photosynthesis. Their research has been published in the current issue of Nature Communications.
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Researchers have discovered that DnaK, a protein of the bacterium mycoplasma, interferes with the mycoplasma-infected cell's ability to respond to and repair DNA damage, a known origin of cancer. The study was published in the Proceedings of the National Academy of Sciences and suggests that bacterial infections may contribute to far more cancers than previously thought.
AMSBIO introduces ALiCE® – a new high yield cell-free protein expression system. Cell-free protein expression (CFPE) is today used by protein chemists to quickly produce small amounts of proteins when screening DNA libraries. However current technologies are limited and there is a need for higher protein expression yields.
RUDN chemists synthesized a range of biologically active molecules called chromones and demonstrated their use in the treatment of Alzheimer's disease. The results of the work were published in the Bioorganic & Medicinal Chemistry journal.
The researchers from the Departments of Chemistry and Biology at the University of Konstanz have fundamental new insights into the degradation of amino acid lysine – carcinogenic on cometabolites as intermediate products.
Researchers from North Carolina State University have created the largest publicly available virtual library of macrolide scaffolds. The library – called V1M – contains chemical structures and computed properties for 1 million macrolide scaffolds with potential for use as antibiotics or cancer drugs.
Heterotrimeric G proteins are important in G protein-coupled receptor signaling, which plays many roles in the detection of various environmental stimuli, including hormones, neurotransmitters, light, smells, and chemical signals.
G protein functions are regulated by interactions with Gip1, a protein that sequesters G proteins to block signaling processes. Many studies have attempted to understand the mechanism for this interaction between G proteins and Gip1; none have provided a clear explanation, until now.
An important component of the microscopic machinery that drives cell death has been identified by Walter and Eliza Hall Institute scientists. Studying the 'pro-death' machinery that caused damaged, diseased or unwanted cells, the research team revealed a protein called VDAC2 was critical for the function of a key pro-death protein called Bax.
Asymmetry plays a major role in biology at every scale: think of DNA spirals, the fact that the human heart is positioned on the left, our preference to use our left or right hand. An international team has shown how a single protein induces a spiral motion in another molecule. Through a domino effect, this causes cells, organs, and indeed the entire body to twist, triggering lateralized behavior. This research is published in the journal Science on November 23, 2018.
Since the time of ancient Egypt, humans have been making and breaking secret codes to retain and gain critical information. Human life itself is based upon a genetic code of DNA or RNA sequences which cells read and translate into proteins—the building blocks of life.
Recent scientific discoveries have revealed the body's mechanisms for transcribing DNA regulated by the "histone code"—different chemical marks on the tails of histone proteins, which are macromolecules within cell nuclei responsible for packaging and structuring DNA.
An enzyme that normally repairs damaged DNA, may be the key to a new treatment for inflammatory diseases. Inflammatory diseases such as COPD and septicemia (blood poisoning) represent a growing threat to public health. Such conditions are commonly the result of an overactive immune system.
Scientists from the University of Bristol have designed a new synthetic glucose binding molecule that brings us one step closer to the development of the world's first glucose-responsive insulin which, say, will transform the treatment of diabetes. Now, the science behind the research has been published in the journal Nature Chemistry.