All news from Bio-Chemistry

Initial Folding Mechanism of Membrane Proteins Uncovered

An international team coordinated by the Interdisciplinary Research Structure in Biotechnology and Biomedicine (ERI BioTecMed) of the University of Valencia has proved how the folding of membrane proteins begins before they are inserted into biological membranes, a fact that has been central to the biochemical research for decades. The study, published in the Nature Communications journal, has been coordinated by Ismael Mingarro, professor of Biochemistry and Molecular Biology at the academic institution.

Research: Bacterial Protein Find Materials for Smartphone

A newly discovered protein could help detect, target, and collect lanthanides, rare-earth metals used in smartphones, from the environment. A newly discovered protein could help detect, target, and collect from the environment the rare-earth metals used in smartphones.

Two new studies by researchers at Penn State describe the protein, which is 100 million times better at binding to lanthanides than to other metals like calcium. The study appears online in the journal Biochemistry, describes its unique structure, which likely plays a role in its remarkable selectivity for lanthanides.

Targeting Chemical Signals To Treat Obesity

New research published in The Journal of Physiology has shed light on how to disrupt chemical signals that affect how much someone eats, which could lead to a method for helping manage obesity. Obesity is one of today's most prevalent public health concerns. In the UK it affects around 1 in every 4 adults and around 1 in every 5 children aged 10 to 11.

The Importins Of Anxiety

According to some estimates, up to one in three people around the world may experience severe anxiety in their lifetime. In a study described today in  Cell Reports , researchers at the Weizmann Institute of Science have revealed a previously unknown mechanism underlying anxiety. Targeting this biochemical pathway may help develop new therapies for alleviating the symptoms of anxiety disorders.

The lysyl oxidase like 2/3 enzymatic inhibitor, PXS-5153A, reduces fibrosis.

Fibrosis is characterized by the excessive deposition of extracellular matrix and crosslinked proteins, in particular collagen and elastin, leading to tissue stiffening and disrupted organ function. Lysyl oxidases are key players during this process, as they initiate collagen crosslinking through the oxidation of the ε-amino group of lysine or hydroxylysine on collagen side-chains, which subsequently dimerize to form immature, or trimerize to form mature, collagen crosslinks.

In Toxoplasma gondii, Protein Targets of Thiazolidinone Derivatives Elaborated

Thiazolidinone derivatives show inhibitory activity (IC50) against the Toxoplasma gondii parasite, as well as high selectivity with high therapeutic index . To disclose the target proteins of the thiazolidinone core in this parasite, researchers explored in silico the active sites of different T. gondii proteins.

Researchers estimated thiazolidinone molecules with an inhibitory effect on invasion and replication of the parasite inside host cells. This enabled us to describe some of the most suitable structural characteristics to design a compound derived from the thiazolidinone core