Researchers have identified a hormone produced by the liver that tells the body to downshift its metabolism when it's expending a lot of energy. The research, scheduled to be published in Nature Metabolism, reveals a potential target for treating metabolic disorders.
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“Biased” G protein-coupled receptor (GPCR) agonists preferentially activate pathways mediated by G proteins or β-arrestins. Here, double electron-electron resonance spectroscopy is used to probe the changes that ligands induce in the conformational distribution of the angiotensin II type I receptor. New research is showing precisely how the crucial cell surface receptors interact differently with various drugs, giving the researchers hope that they may be able to tailor more specific medications for heart patients.
Consumption of one egg every day appears to associate with a blood metabolite profile that is related to a lower risk of type 2 diabetes, a new study conducted at the University of Eastern Finland shows. The findings were published in Molecular Nutrition and Food Research.
Researchers report that adding to the lysophospholipid form of EPA (LPC-EPA) to increase dietary levels of EPA in the brain 100-fold in mice. Getting enough of the omega 3 fatty acids DHA and EPA into the brain to study its effects on conditions like Alzheimer's and depression which they have been shown to help – is no easy task. While these are fatty acids, there is scant evidence that these supplements actually increase DHA or EPA in the brain.
A giant toadstool that swallow up vitamins and nutrients in the intestines and kidneys. This is how the receiver, which absorbs B12 vitamin in the small intestine, looks. For the first time, researchers have had an insight into an unknown biology which has survived hundreds of millions of years during the evolution of life.
A jagged little protein appears to be key to how to stem cancer cells differentiate and enable metastasis, according to researchers at Rice University and the Duke University School of Medicine.
Leuven led by Professor Bart De Strooper (VIB-KU Leuven) has identified a new role for PARL, a protein that has been linked to Parkinson's disease. In this week's edition of the Proceedings of the National Academy of Science , they report that mice lacking PARL display specific problems in the nervous system reminiscent of Leigh syndrome instead.
Alzheimer's disease is caused by aggregates of amyloid-beta peptides. This aggregation is accelerated at a cell membrane surface. The research group at ExCELLS revealed the reason of this phenomenon by molecular dynamics simulations and NMR experiments.
Anxiety disorders are severe mental disorders in which patients suffer from intense fears and anxiety or from sudden, inexplicable panic attacks. In extreme cases, the affected individuals barely leave their homes, which have serious consequences for their relationships with family and friends as well as for their professional lives. Scientists at the Max Planck Institute for Experimental Medicine in Göttingen have now identified a synaptic protein which, when inactivated, has an anxiolytic effect in mice.
Kinetoplastid and apicomplexan parasites include protozoans which are responsible for human diseases, and cause a serious impact on human health and the socioeconomic growth of developing countries. Chemotherapy is the main option to control these pathogenic organisms. The organisms' nuclear metabolism is considered a promising area for the provision of antimicrobial therapeutic targets.
Folate deficiency can severely affect one of the most important processes in the body, cell division, researchers from the University of Copenhagen have demonstrated in a new study published in the scientific journal PNAS. In the study, the researchers show that folate deficiency can cause problems in connection with cell division and DNA replication. In fact, it creates far more damaging chromosomal abnormalities than previously known.
Researchers a have reported the first in crystallo thermodynamic analysis of copper amine oxidase catalysis using a non-cryocooled technique. The method, which analyzes protein crystals coated with a water-soluble polymer, rather than cryogenically cooled crystals, can be temperature-controlled, allowing for conformational changes to be monitored over a range of temperatures. Additionally, the conditions show parallels with the cytosol, meaning that the approach could provide a useful model for protein behavior in cells.