Metabolic Enzymes Tied To Fatty Liver Disease

The researchers conducted the study, to determine if the exposure to specific chemicals enhances obesity. Specifically, they wanted to identify the role of Cyp2b in unsaturated fatty acid metabolism enzymes, regardless of diet. Some chemicals could inhibit the gene, an event shown in the experiment with Cyp2b-null mice.

The research study team using a laboratory mouse model to explore the role of Cyp2b gene in obesity. It is an enzyme involving in metabolism; particularly the chemical detoxification in the body. The researchers treated wildtype and Cyp2b-bull mice with a normal or high-fat diet for 10 weeks.

Metabolic enzymes

YP2B metabolizes enzymes multiple endo- and xenobiotics, and recent data suggests that repression of Cyp2b activity increases dyslipidemia and age-onset obesity, especially in males. After, they determined the molecular and metabolic changes that happened. They found that the male high-fat-diet-fed Cy2pb-null mice weigh 15% more than; the wildtype mice given a high-fat diet.

The greater weight has been linking to an increase in white adipose tissue. There were many potential implications for human health. When the researchers checked the blood samples of the mice; they found increased leptin, cholesterol, and ketosis in male Cyp2b-null mice, compared to wildtype mice.

Liver triglycerides

Furthermore, the liver triglycerides in male Cyp2b-null mice were higher than their counterparts, hinting a role of Cyp2b in fatty acid metabolism, despite having the same diet. There is a suggestive result of fatty liver disease; progressing is present in normal diet-fed Cyp2b-null; male rats like the one in high-fat diet fed wildtype counterpart.

Cyp2b must be signaling something and telling the fat to go someplace, indicating that Cyp2b has dual roles; metabolizing toxicants and chemicals in the environment and pharmaceuticals; but it is also involving in the metabolism of lipids and probably involving in signaling to tell us how to distribute fat. The rate of obesity is continuously increasing; hence, studies are focusing on finding causative factors that can provide insight into obesity. Also, determining these causes may help in the formulation of treatments and preventive measures to curb the worldwide epidemic.