A special protein, PEX3, is long believing not to exist in the parasite, trypanosome; that which can be transmitting through insect bites. But, the researchers of the study finding that the protein is present in the parasite and is crucial for its viability. PEX3 is an important component of the cell biology of living things, including plants, humans, and trypanosome.
It works by regulating peroxisomes that help in the break down of amino acids and fatty acids to create energy. In trypanosomes, they contain special peroxisomes that are important in one process converting glucose in a host’s body into energy. Hence, if therapeutics target PEX3, it could help in killing the parasite, without hurting or harming the host.
Important component of cell
In light of the discovery, targeting PEX3 could be the key to finding the cure for various parasitic diseases like Chagas disease, African sleeping sickness, and leishmaniasis, which all threaten millions of people worldwide. Finding PEX3 in trypanosomes has been very difficult. People have been looking for years and could not find it. Some people said it didn’t exist, that it was a different mechanism, but we believed that the simplest answer was that we just hadn’t found it yet.
Neglected tropical diseases form a group of infectious parasitic diseases; that affect a large percentage of the world population, mostly in emerging nations. Sleeping sickness affects millions in sub-Saharan Africa and is caused by the protozoan parasite, Trypanosoma brucei; which is transmitted by the tsetse fly. If left untreated, sleeping sickness is fatal. Animal trypanosomiases caused by other members of the genus Trypanosoma place; additional financial and social pressures on the nations of this region.
Genus Trypanosoma place
Current drugs using to treat sleeping sickness are restricting in their utility because of toxicity; severe side effects, and complicated administration. Moreover, neglected tropical diseases affect mostly those countries; with the least financial or infrastructural resources to develop or deliver new therapies. Therefore, the identification of novel drug targets and the development of new drugs for these targets are pressing priorities.
However, trypanosomes are unicellular parasitic protozoa from the Genus of the Trypanosomatidae Class. They are rampant in tropical areas, including the African continent. It is well-known as the causative agent of various human and animal diseases. For instance, trypanosomes cause sleeping sickness, which first emerged in Africa. It is now endemic in 36 sub-Saharan Africa countries, where the tsetse flies transmit the illness.