An international and interdisciplinary team working at the Earth-Life Science Institute (ELSI) at the Tokyo Institute of Technology has modeled the evolution of one of biology’s most fundamental sets of building blocks and found that it may have special properties that helped bootstrap itself into its modern form. All life on Earth uses an almost…
According to the study, researchers developing an new method; for imaging the biological molecules. Where new method for creating images of molecules in cells or tissue samples. The method is basing on the use of DNA snippets and is called DNA microscopy. The new method involves researchers in the first stage mixing up a cell or…
According to the study, the researchers making possible by an array of different structural and molecular biology techniques, with the structural component being carried out at Diamond Light Source. The team used three different techniques, Cryo-EM; crystallography and SAXS which are powerful when using on their own; but even more so in combination when addressing…
As sugar compounds in breast milk play a crucial role in the development of a healthy gut bacterial community; and contribute to the maturation of the immune system in infants. But the study explaining that transport proteins provide key to improve infant formula; the function of key transport proteins that mediate the uptake of nutrients…
Cellular functions depend on the functionality of proteins, and these functions are disturbed in diseases. A core aim of cell biological research is to determine the functions of individual proteins and how their disturbances result in disease. One way to study protein functions is to examine the effects of rapidly removing them from cells. During…
According to the study, WNT signaling pathways play important roles in cell growth, development and cancer. The classical or canonical WNT pathway and its atypical; non-canonical counterpart share a protein called DVL2 that “transduces” or converts one kind of signal to another. shown that two other proteins; USP9X and WWP1, act on DVL2 to regulate…
The enzyme transhydrogenase plays a central role in regulating metabolic processes in animals and humans alike. Malfunction can lead to serious disorders. In every cell, the mitochondria continuously break down molecules derived from food to generate energy as well as to produce new molecules that serve as building blocks of cells. But by balancing these two…
According to the study it is showing that the synthesis of a potential immunosuppressive agent; by modification of a naturally occurring compound. In this endeavour, the researchers have employed a masking trick to “hide” a reactive species inside the target molecule. Particularly fascinating are the so-called Natural products. These are substances producing by living organisms;…
A special protein, PEX3, is long believing not to exist in the parasite, trypanosome; that which can be transmitting through insect bites. But, the researchers of the study finding that the protein is present in the parasite and is crucial for its viability. PEX3 is an important component of the cell biology of living things,…
The activation of mTor complex 1 in the cell is central to many vital processes in the body such as cell growth and metabolism. Overactivity of this signaling pathway can result in diseases such as in diabetic insulin resistance and cancer. This has now discovering how inactivation of a certain lipid kinase promotes mTor complex…
Study that assembling more complex branching structures from PER-generating concatemers that contain higher numbers of binding sites for fluorescent imagers; Finding that lighting up proteins with Immuno-SABER. To better understand how tissues and organs develop, fail to function, and regenerate over time, researchers would like to visualize their constituent cells repertoires of molecules within 3-D…
The study scientists discovering the basics; explaining that how the pressure sensing Piezo proteins will be working. By this the study illuminating the basic mechanism of the Piezo proteins; which function as sensors in the body for mechanical stimuli such as touch; bladder fullness, and blood pressure. The discovery is a feat of basic science…