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Stem cells

MSCs from Aged Individuals Acquire A Rejuvenation Signature

Primary mesenchymal stem cells (MSCs) are fraught with aging-related shortfalls. So, human-induced pluripotent stem cell (iPSC)-derived MSCs (iMSCs) have been shown to be a useful clinically relevant source of MSCs that circumvent these aging-associated drawbacks. However, to date, the extent of the retention of aging-hallmarks in iMSCs differentiated from iPSCs; derived from elderly donors; remains…

Anatomy

Parvalbumin-containing Cells: Surprising Changes in Blood Volume, Flow

Alzheimer’s disease and schizophrenia are some of the most common brain disorders; and have association with problems in cells that contain a type of protein; called parvalbumin. These parvalbumin-containing cells account; for almost one-tenth of the cells in your brain; however, relatively little is; known about what parvalbumin cells do. By stimulating mouse brains with…

Turning a patient's own cells

Turning A Patient's Own Cells into Cancer Fighters

The next cancer therapy could be a patient’s own cells. Tactiva Therapeutics, a Buffalo-based immuno-oncology startup; is developing a personalized cancer treatment based on engineered immune cells derived from patients’ own cells. The company’s approach involves attaching proteins called receptors to these cells. The receptors target antigens present in cancer cells, enabling the patient’s immune…

Mutation

Mutation: The Way of Healthy Blood Cell Maturation

In the veins, stem cells constantly mature and develop into; blood cells that are necessary for the body to work properly. Now, researchers from the University of Copenhagen and EMBL in Heidelberg have discovered; exactly how a specific mutation in stem cells in the blood; can obstruct this maturation process. In a new study, the…

Stem cells

Specific Mutation Obstructs Healthy Blood Cell Maturation

In the veins, stem cells constantly mature and develop into different blood cells; that are necessary for the body to work properly. Now researchers from the University of Copenhagen and EMBL in Heidelberg; have discovered exactly how a specific mutation in the stem cells in the blood can obstruct; this maturation process. In a new…

Anatomy

Creating Blood Vessels on Demand

Vascularization is a critical step in the restoration of cellular homeostasis. Several strategies including localized growth factor delivery, endothelial progenitor cells; genetically engineered cells, gene therapy; and prevascularized implants; explored to promote revascularization. But, long‐term stabilization of newly induced vessels remains a challenge. It shows that fibroblasts and mesenchymal stem cells can stabilize newly induced…

A soft spot for stem cells

Stem Cells Helps Cornea Healing

New research led by scientists at Newcastle University; UK reveals a potential revolutionary way to treat eye injuries and prevent blindness; by softening the tissue hosting the stem cells; which then helps repair wounds; inside the body. The team discovered that the simple application of a tissue-softening enzyme; collagenase, prevents the loss of corneal stem…

Stem cells

Endothelial Progenitor Cells Delay ALS Disease Progression

Transplantation of human bone marrow-derived endothelial progenitor cells (EPCs); into mice mimicking symptoms of amyotrophic lateral sclerosis; helped more motor neurons survive and slowed disease progression; by repairing damage to the blood-spinal cord barrier; University of South Florida researchers report. The new study, published in Scientific Reports, contributes to a growing body of work exploring…

cancer patient

First Cancer Patient Treated with Stem-cell Derived NK-Cells

After 10 years in remission, Derek Ruff’s cancer returned, this time as stage IV colon cancer. Despite aggressive rounds of chemotherapy, palliative radiotherapy and immunotherapy, his disease progressed. In February 2019, as part of a phase I clinical trial at Moores Cancer Center at UC San Diego Health; Ruff became the first patient in the…

New way to increase population

New Way to Increase Population of Intestinal Stem Cells

Cells that line the intestinal tract are replaced every few days; a high rate of turnover that relies on a healthy population of intestinal stem cells. MIT and University of Tokyo biologists have now found; that aging takes a toll on intestinal stem cells and may contribute to increased susceptibility to disorders; of the gastrointestinal…

Transplant

Less Likely To Have Matched Stem Cell Donors

Although the pool of registered bone marrow donors has increased in recent years; a new study suggests that most people of southern-European and non-European descent; are unlikely to have a suitable match if they need a life-saving bone marrow transplant. If an immediate registry search does not identify a donor; alternative transplant strategies should be…

Immune-repelling protein

Survival Of Human Stem-cell-derived Beta Cells

Encapsulating human stem-cell-derived beta cells in microcapsules; made with a protein that repels key immune cells restored glucose metabolism; in diabetic mice and protected the cells from immune system attack; preventing the buildup of inflammatory fibrotic tissue that has plagued previous trials; of encapsulated beta cells. However, a team of Massachusetts General Hospital (MGH) investigators…