All news from Anatomy

Cancer

Tissue Environment Plays Important Role in Tumor Formation

A team of Florida State University researchers used a simple tumor model to show the importance of tissue microenvironment in primary tumor formation. In the journal Developmental Cell, FSU researchers explain how certain signaling pathways define tumor hotspots, tissue microenvironment favorable for tumorigenesis, and show that simple stimulation of a protein can lead directly to tumor formation. Notch:…

Anatomy

Same Brain Cells Active During Sleep and Exploration in Mice

Most brain neurons are active in waking; but hypothalamic neurons that synthesize the neuropeptide melanin-concentrating hormone (MCH) are; claimed to be active only during sleep; particularly REM sleep. Here we use deep-brain imaging to identify changes in fluorescence; of the genetically encoded calcium (Ca2+) indicator GCaMP6 in individual hypothalamic neurons; that contain MCH. An in-vitro…

Anatomy

Researchers Reveal Key to Targeting Dormant Cancer Cells

An international team of scientists has uncovered the unique set of genes that keeps some cancer cells dormant. Led by Associate Professor Tri Phan and Professor Peter Croucher at the Garvan Institute of Medical Research in Australia, in collaboration with Professor Ido Amit at the Weizmann Institute of Science in Israel, the research may reveal…

Anatomy

The Role for A Rare, Influential Set of Bone Marrow Cells

Researchers have defined the roles of various cells in the bone marrow; that thought to control the fate of the nearly half million blood cells; that develop there each day. Scientists at NYU School of Medicine behind the new work say little had known about the fraction of cells; examined in the study, the “microenvironment”;…

Anatomy

Factors Behind Embryonic Stem Cell State

Embryonic stem cells (ESC) have the ability to self-renew, and, being pluripotent have the potential to create almost any cell type in the body. So, the embryonic stem cell state is; established and maintained; by multiple regulatory networks; that include epigenetic regulators; the function of these epigenetic regulators; though has not; been well-defined. However, an…

Coelacanth reveals

Coelacanth Reveals New Insights into Skull Evolution

An international team of researchers presents the first observations of the development of the skull and brain in the living coelacanth Latimeria chalumnae. Their study, published in Nature, provides new insights into the biology of this iconic animal and the evolution of the vertebrate skull. The coelacanth Latimeria is a marine fish closely related to tetrapods,…

Cancer

'Artificial Lymph Node' to Fight Cancer

In a proof-of-principle study in mice, scientists at Johns Hopkins Medicine; report the creation of a specialized gel that acts like a lymph node to successfully activate; and multiply cancer-fighting immune system T-cells. The work puts scientists a step closer, they say; to injecting such artificial lymph nodes into people; and sparking T-cells to fight…

RNA sequencing

Novel Genes And Pathways in Celiac Disease

Researchers at the Mucosal Immunology and Biology Research Center at MassGeneral Hospital for Children (MGHfC) have discovered novel genes and pathways related to early stages in the development of celiac disease and the ongoing inflammation and comorbidities associated with the condition. he findings, published in PLOS One, include analyses of RNA sequences in duodenal biopsies…

Anatomy

Growing A Cerebral Tract in A Microscale Brain Model

It takes a lot of connections to create human intelligence. Brain function depends on contacts between multiple regions within the brain. To study how this connectivity is possible — and how it can go awry — international researchers led by The University of Tokyo have grown a working model of a cerebral tract in the…

Anatomy

Crucial Link Between Brain And Gut Stem Cells

The organs in our bodies house stem cells that are necessary to regenerate cells when they become damaged, diseased or too old to function. Researchers at Rutgers University have identified a new factor that is essential for maintaining the stem cells in the brain and gut and whose loss may contribute to anxiety and cognitive…

Anatomy

Skin Properties: Limit Cancer and Aid Stem Cell Regeneration

Two images published in a Cell Stem Cell paper summarize years of relentless questioning on how skin stem cells regenerate, which has driven much of the research of Valentina Greco. The side-by-side images feature individual mouse cells in grayscale microscopy; and those same cells rendered in a pastel; color-by-numbers image that illustrates skin stem cells’ self-renewal…

Anatomy

Elite Hospitals Plunge into Unproven Stem Cell Treatments

The online video seems to promise everything an arthritis patient could want. The six-minute segment mimics a morning talk show, using a polished TV host to interview guests around a coffee table. Dr. Adam Pourcho extols the benefits of stem cells and “regenerative medicine” for healing joints without surgery. Pourcho, a sports medicine specialist, says…