All news from Anatomy

Developmental biology

Spaceflight Microgravity On Stem Cells And Tissue Regeneration

Studying behavior of stem cells during spaceflight and in simulated microgravity is necessary to foresee how human stem cells, which represent the primary source of our regeneration, will respond to spaceflight in vivo; it is also necessary to support biotechnological assays. Research in this area utilizes a wide range of cell models, most common being…

multiple sclerosis

Brain Stem Cells Age Faster: Multiple Sclerosis Patients

Brain stem cells in people with the most severe form of multiple sclerosis look much older than they really are, according to a study led by UConn Health and published in the Proceedings of the National Academy of Sciences (PNAS). The prematurely old cells act differently in the brain than normal ones, and could be the key…

Leukemia

'Sleeper Cell' Cancer Stem Cells: In Chronic Myelogenous Leukemia

Most patients with chronic myelogenous leukemia can be; treated with tyrosine kinase inhibitors. These drugs are highly effective and lead to deep remission and prolonged survival. Yet quiescent leukemic stem cells persist in these patients, and they therefore must continue inhibitor treatment to maintain remission. These ‘sleeper cell,’ quiescent leukemic stem cells are maintained in…

Tissue regeneration

Nanofibrous Membrane Could Enhance Periodontal Tissue Regeneration

The management of periodontal tissue defects that result from periodontitis represents a medical and socioeconomic challenge. Concerted efforts have been and still are being made to accelerate and augment periodontal tissue and bone regeneration, including a range of regenerative surgical procedures, the development of a variety of grafting materials, and the use of recombinant growth…

Leukeima

Squishing Blood Stem Cells: Facilitate Harvest For Transplants

Scientists at Winship Cancer Institute of Emory University, Children’s Healthcare of Atlanta and Georgia Tech have found that modulating blood-forming stem cells’ stiffness could possibly facilitate mobilization procedures used for stem cell-based transplants. Temporary squishiness could help drive blood-forming stem cells out of the bone marrowand into the blood, but the cells need to be stiff to…

Stem cells

'Inflamm-aging': Loss Of Bone Healing Ability

Increases in chronic inflammation—not the passage of time—is the main reason why injured bones do not heal as well with age. This is the finding of a study in mice and humans published in the Proceedings of the National Academy of Sciences (PNAS). The results revolve around the known breakdown, due to wear and tear, of…

Stem cells

Cell Therapy: Replace Need For Kidney Transplants

Wake Forest Institute for Regenerative Medicine (WFIRM) scientists are working; on a promising approach for treatment of chronic kidney disease; regeneration of damaged tissues using therapeutic cells. By harnessing the unique properties of human amniotic fluid-derived stem cells; WFIRM scientists have demonstrated; that the cells could potentially help recover organ function in a pre-clinical model…

Developmental biology

Genetic Switches: Control Process Of Whole-body Regeneration

When it comes to regeneration, some animals are capable of amazing feats — if you cut the leg off a salamander, it will grow back. When threatened, some geckos drop their tails as a distraction, and regrow them later. Other animals take the process even further. Planarian worms, jellyfish, and sea anemones can actually regenerate…

Stem cells

Appropriate Supply Of Blood Cells: A Regulatory Molecule Ensures

The body needs to create a continuous supply of blood cells to enter circulation. Blood cells have a wide variety of functions ranging from supplying oxygen to tissues; fighting infections, and enabling the blood to clot upon injury. Avoiding deficiency of these cells or their excessive proliferation; must involve a strict regulatory mechanism; but much…

Developmental biology

Secrets Of Early Life: Half A Teaspoon Of Blood

A global team of scientists have mapped the developmental pathway of a newborn’s life for the first time. The research, published in Nature Communications, could transform our understanding of health and disease in babies. Co-led by the MRC Unit The Gambia at the London School of Hygiene & Tropical Medicine, the new study included lifting the…

Mesenchymal stem cells

Novel Regulatory Factor In Bone Formation

Mesenchymal stem cells; characterized morphologically by a small cell body with a few cell processes that are long and thin. The cell body contains a large, round nucleus with a prominent nucleolus, surrounded by finely dispersed chromatin particles, giving the nucleus a clear appearance. The remainder of the cell body contains a small amount of…

Anatomy

Complex Brain Organoids: Creating Increasingly

Brain organoids are; 3D self-assembled structures that recapitulate crucial molecular and cellular steps of brain development. Protocols exist to create brain organoids in a dish from human pluripotent stem cells derived from patients and healthy individuals. The incorporation of single-cell sequencing, genome editing, and optogenetics could improve the application of brain organoids. Genetic basis of…