Brain homeostasis and damage repair depend on the generation of new neurons and glia by neural stem cells.But most NSCs are found in adults to be quiescent but can enter proliferation if prompted by extrinsic and intrinsic stimuli; but brains are notoriously bad at regenerating cells that have been lost through injury or disease.
In this research, study on neural replenishment depends on the ability of NSCs to tightly control; the balance between quiescence and proliferation;There are some therapies using neural stem cells (NSCs) hold the promise of replacing lost cells; scientists need to better understand how NSCs behave in the brain in order to develop effective treatments.
Homeostasis And Damage Repair
Where NSCs produce neurons (nerve cells) and surrounding glial cells in the brain. By understanding how NSCs work; it could pave the way for therapies to speed up the neurons’ and glial cells; regeneration study analysis of identified individual cells taken directly from living tissues; at desired time points allows us to precisely examine the transcriptional control at the crossroads of crucial cell fates.
Due likely to the reduced sample number and single cell cDNA amplification variability; by identifying genes meeting significance showing consistent expression changes across replicates; and the regulation of all of the targets testing was independently validating.
But some mammalian genes and partial overlap with orthologs reporting to be deferentially expressing in mouse quiescent versus activating NSCs; suggest that the data set is also a valuable resource for mammalian NSC research.As in mammals, Drosophila NSCs are dependent on niche signals relaying external stimuli for both quiescence and reactivation.In response to a nutritional cue, niche glia cells activate InR/PI3K/Akt signaling in NSCs to promote reactivation.
However, this research study revealing that STRIPAK molecules are essential to enable reactivation in NSCs; study working to expand our findings and bring us closer to the day when human neural stem cells can be controlling and efficiently using to facilitate brain damage repair, or even prevent brain cancer growth that is fueled by stem-like cells.