A recent study examined that a drug used to treat inflammatory bowel disease, arthritis, and vasculitis as well as to prevent organ rejection in transplant patients has been identified as an important contributor to skin cancer development. The study was published in Nature Communications.

They identified a `strong case for an association' between the drug azathioprine and the mutational signature found in cases of cutaneous squamous cell carcinoma (cSCC), a common form of skin cancer.

Use Of Azathioprine

It was already known that the use of azathioprine leads to increased photosensitivity to UVA light, probably contributing to the development of skin cancers. This new study finds that the use of azathioprine leaves a molecular fingerprint in skin cancers, further implicating it in cSCC development.

They recommend all physicians give appropriate advice on UVA avoidance including year-round sun protection for their patients on azathioprine. As with all medications, the risks must be balanced against the benefits, particularly with the need to treat potentially life-threatening diseases with an effective drug.

Skin Surveillance

It is important that sun protection, skin surveillance and early diagnosis/lesion removal are part of the routine management of patients on azathioprine. cSCC is a common skin cancer with more than 40,000 new cases diagnosed annually in the UK, with significant health economic implications.

It's important to protect your skin from the sun when it's strong, especially if you burn easily or are taking medications which make you more sun-sensitive. The most effective protection is to spend time in the shade and cover up with a hat, long-sleeved top, and sunglasses.

For the bits you can't cover, use sunscreen with at least four stars and SPF 15 or higher for protection against both UVA and UVB rays. Importantly, this new study also reveals the molecular landscape of cSCC and highlights potential targets that may be developed for future therapeutic approaches to manage cSCC.

Different carcinogens leave a different `mutational signature' in cancer. By studying these signatures, researchers can start to determine what the causes of cancer are. The researchers were able to carry out mutational signature analysis of cSCC tumors from 37 patients, many of whom had been on azathioprine. They found a new mutational signature, Signature 32, which correlated with time on azathioprine therapy.

Long-term Drug Therapy

Although patient numbers were small and these findings should be verified in a larger independent cohort, this molecular study provides a strong case for an association between this novel mutational signature and long-term azathioprine use.