The study involves the surgery for nasal polyposis, researchers estimated the effects of Spray Cryotherapy (SCT) on management of healing in patients with nasal polyposis who undergone functional endoscopic sinus surgery. Nasal Polyposis is a benign tumor in nasal or paranasal mucosa, which confronts difficulties in management of healing after treatments with surgery.

Nasal polyposis (NP) is a subgroup of chronic rhino sinusitis family which is defined as swellings, inflammation and discharge of nasal or paranasal mucosa. The exact etiology of this problem remains unknown however it has been proven that eosinophils play a pivotal role in pathogenesis of the disease. 

The prevalence rate of NP has been reported 0.2% to 4% in different studies which has been also reported to be more common in male population. NP is divided into two types; symptomatic and asymptomatic NP, the symptoms of NP include, but no limited to, nasal packing or obstruction, sneezing, post-nasal drip, congestion, anosomia/hyposmia and facial pressure and pain.

Cryotherapy is a new modality and a novel method used to healing of wounds and normalization of mucosa in aerodigestive tract. Spray cryotherapy (SCT) includes a cryoprobe and gas cryogen (nitrogen or carbon dioxide), utilized based on Joule-Thompson which effects on contact tissue ablation by cooling and freezing in temperature of −40 to −90?°C.

Here in this study, we to evaluate the outcomes of SCT usage in management of postoperative healing in 40 patients undergoing surgical resection of NP. Our assessments were Lund-McKay and SNOT-22 scores; therefore, we showed that Lund-McKay and SNOT-22 scores in SCT group were significantly lower than placebo group meaning a better outcome of the surgery.

There, they concluded that these scores were significantly different after operations suggesting SCT as an enhancing method for wound healing. Another study evaluated cryotherapy as Maxillary Antrostomy Patency in a Rabbit Model of Chronic Rhinosinusitis.

In this study authors reported enhanced maxillary antrostomy area in the group that was under administration with cryotherapy 4?weeks after surgery. Also, the authors didn't report any side effects postoperatively. In conclusion, the study explained SCT is an effective method with fewer or no reported side effects in management of benign and malignant tumors and injuries, especially with a better effect in mucosal tissue.

They conclude that SCT are more effects on management of NP after functional endoscopic surgery. There were also no serious adverse effects in this technique. So as a suggestion, usage of SCT might be an effective and safe method in healing management of NP after surgeries.