When people experience stress, the adrenal glands that sit on top of the kidneys release a steroid hormone called cortisol. However, our latest study shows that people who have experienced high levels of trauma in childhood, and who have attempted suicide, tend to release less cortisol when put under stress. These findings build on our earlier work that showed that the stress response system may be "faulty" or "damaged" in people who have recently tried to take their own life.
Researchers looked at whether stress and childhood trauma were related to the risk of suicide. Childhood trauma has been linked to a damaged or faulty stress response system in people with depression later in life, but little is known about it in relation to suicide.
In our study, 160 people were grouped according to whether they had a history of previous suicide attempt, had thoughts of suicide but did not attempt suicide, or had neither attempted nor considered suicide (the controls).
Participants were asked to complete a questionnaire about the emotional, physical and sexual abuse they may have suffered as a child or as a teenager, as well as emotional and physical neglect. They were then asked to complete a stressful task in the laboratory. We measured the participants' cortisol levels from saliva before and during the task.
Our analysis of the results showed that people who had attempted suicide in the past released low levels of cortisol when stressed compared with controls. The lowest levels were in people who had tried to take their own life within the past year. More alarmingly, those people who released lower cortisol when stressed in the laboratory reported higher levels of wanting to die – known as "suicide ideation" – four weeks later.
We also found very high levels of childhood trauma in people vulnerable to suicide, in particular in people who had previously made a suicide attempt. Nearly 80% of people who had attempted suicide had experienced at least one type of childhood trauma compared with less than 40% in those who had thought about suicide only, and less than 20% in the controls.
People who reported more than one moderate or severe type of childhood trauma released the lowest amount of cortisol during the stress test and during rest. Importantly, these effects were not explained by current depression.
Glimmer of hope
These findings suggest that the stress response system may be "broken" or impaired in people at risk of suicide. While this is concerning, the difference between the cortisol levels in people who had recently attempted suicide compared with those with a lifetime history are promising because they suggest that the stress response system may recover over time.
The reason these results are important is because people's ability to release cortisol when stressed has been linked to poor mental control (ability to inhibit or stop inappropriate or maladaptive behaviour and responses), emotional processing (ability to control emotions) and risky behaviours (such as drug taking, alcoholism and being impulsive) – all factors associated with suicide risk.
Our findings suggest that the amount of cortisol a vulnerable person releases when stressed may be an additional biological marker of suicide that could help identify those people at risk of suicide. For example, it might be possible to include a cortisol stress test as part of an assessment of people vulnerable to suicide.
Important next steps for prevention might involve developing suicide prevention treatments that restore cortisol levels. These may involve psychological therapies, such as mindfulness, that have been shown to hold great promise for improving health and well-being.
Alternatively, a future avenue of research might look at whether pharmacological interventions, such as providing cortisol supplements, might help repair the stress response system in people vulnerable to suicide.