Scientists have now identified what triggers such changes. Age-related changes in the peripheral nerves can drastically reduce the quality of life. The average life expectancy is at an all-time high and rising. This is associated with an increase in age-related diseases of the nervous system such as Alzheimer's and other forms of dementia. However, such pathological degenerations do not only affect the brain.
Progressive muscle weakness
Although the consequences of age-related peripheral nerve degeneration have a massive impact on the quality of life in old age as well as for the economy, its causes have not yet been investigated systematically. The peripheral nervous system, which is responsible e.g. for muscle and skin innervation, also has an increased risk of degenerating as they age.
Macrophages under the microscope
They surveyed the changes taking place in the peripheral nerves of people aged between 65 and 79," Rudolf Martini describes his team's approach. During this, the researchers encountered an increased number of macrophages in the samples.
Macrophages are cells of our body's immune system that engulf, digest and dispose of microbes, foreign substances, cellular debris, aging cells etc. They set inflammatory responses in motion, help heal wounds and cleanse the tissue. Unfortunately, however, they also cause damage to some diseases.
To find out whether this also applies to age-related nerve degeneration, the scientists performed an experiment on mice. For this purpose, they looked more closely at the nerves of 24-month-old mice which is an advanced age for mice. It turned out that the age-related changes in the mice's peripheral nerves are very similar to those in humans.
As in their human counterparts, the number of macrophages was increased in the mice. Also, the older animals had less strength than their younger siblings and their motor endplates, the synapses connecting nerves and muscle fibers, were also less intact.
Successful therapy in the animal experiment
Researchers examined whether macrophages are actually responsible for triggering these changes. To this end, they added a special substance to the mice's food at the age of 18 months which causes the macrophages to die off. Accordingly, the animals had the more muscular strength and their motor endplates were in better shape compared to the untreated control mice.
The study not only shows a causal relationship between inflammatory responses in aging nerves and degenerative aging processes but also that this condition can be treated. In their opinion, a targeted, highly specific treatment of age-related, macrophage-induced inflammation can improve the structure and function of nerves, and along with that, increase mobility and quality of life.
Important for infections and diabetes
However, the interpretation of these findings also allows drawing more far-reaching conclusions: Because infections or chronic age-related diseases such as diabetes often involve inflammatory responses as well, they present an additional risk for aging nerves. Therefore, the researchers hope that their findings will contribute to triggering research and development of substances that target macrophages in particular.
They are planning to perform further experiments to find out how age-related inflammatory responses in nerves are caused. They want to figure out which cells in the nerves are responsible for the increased macrophage count and whether there are other options to treat the degenerative change besides drugs.
In addition to the important insights into the causes of peripheral neuropathy in age, this study again shows that accurately planned animal experiments are indispensable to develop therapies to treat previously incurable human diseases.