According to a research, a protein known to drive nerve cell survival in the brain and spinal cord might also protect failing hearts in children and young adults with Duchenne muscular dystrophy.
Children with Duchenne muscular dystrophy often begin to lose muscle strength and function between ages three and five. Duchenne cardiomyopathy follows, in which patients' heart muscles stiffen and lose function. Cardiomyopathy often leads to heart failure and death in children and young adults with the disease.
It's hard to predict when cardiomyopathy will happen in Duchenne patients, but when it does, there are no effective or specific treatments aimed at preserving heart function at this time. Gaining a greater understanding of how cardiomyopathy occurs in these patients could help to develop future treatment.
Brain-derived Neurotrophic Factor
They studied a small group of Duchenne muscular dystrophy patients and measured blood levels of the protein brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin kinase B (TrKB). The receptor, TrKB, attaches to BDNF which then sends chemical signals to the cells to protect against cell death.
Protein Protecting Heart Cell
Researchers have long known that BDNF is important for brain function. It helps brain cell survival and growth and promotes memory. Our research shows BDNF also appears to be heart protective and heart specific. Data suggests the more there is, the better the heart function in the patient.
In addition, researchers examined whether it was possible to increase BDNF and if it might preserve heart function in these patients by studying mice that mimicked human Duchenne patients' disease progression..
The fact that DHF can be delivered orally is important for Duchenne patients.These children are suffering from muscle degeneration. Echocardiography showed DHF preserved the heart's function, compared to mice that didn't receive DHF. When researchers gave mice the TrkB inhibitor K252a, the opposite occurred and heart function declined.
In general, they found BDNF and TrkB are required for the heart's strong and vigorous contraction (contractility) and survival of cardiomyocytes the heart's cells.