All news from Anaesthesiology

Increased Number and Activity of a Lateral Subpopulation of Hypothalamic Orexin

A study in cocaine-addicted rats reports long-lasting increases in the number of neurons that produce orexin, a chemical messenger important for sleep and appetite that may be at the root of the addiction. The study was published in Biological Psychiatry.

Restoring the number of orexin neurons to normal, or blocking orexin signaling in the brain, made the rats no longer addicted, suggesting the increased orexin neurons to be essential brain changes that cause the addicted state.

Unique Protein Synthesis Machinery In Mitochondrial Ribosomes

A team of researchers has resolved its very special structure for the first time. Sleeping sickness-causing parasites contain an unusual protein synthesis machinery. Ribosomes are among the most important molecular machines within the cell that hardly changed in the course of evolution. Their function is to read copies of our genes, or building plans, and to translate them into proteins. The study was published in Science.