All news from Anaesthesiology

Virus Destabilizes the Genome, Mechanism Uncovered

New insights into how Kaposi's sarcoma-associated herpesvirus (KSHV) induces genome instability and promotes cell proliferation could lead to the development of novel antiviral therapies for KSHV-associated cancers, according to a study published in the open-access journal PLOS Pathogens by Erle Robertson of the University of Pennsylvania, and colleagues.

Genetic Information Shared by Dangerous Bacterium, Findings

Bacteria are very sneaky in their efforts to develop resistance to antibiotics. Some strains of bacteria package up the genetic instructions for how they defend themselves and cause disease, and pass this information on to neighbouring, naïve, bacteria – essentially gifting their colleagues with the defences they need to survive against our medical armoury of antibiotics.

Enzyme Plays Role In Cancer Development

In a new study, researchers have discovered how an enzyme that plays a key role in cancer development functions. The researchers hope the new knowledge will lead to the design of more precise drugs.

Researchers at the University of Copenhagen have come closer to understanding how an enzyme that appears to be important to cancer development behaves inside the cells. The new study, published in the scientific journal Nature Communications, shows first of all that the enzyme METTL13 helps control the formation of new proteins in the cells.

Human Heart Muscle Grown from Patient-Specific Stem Cells

Columbia biomedical engineers grow first human heart muscle from stem cells that show critical hallmarks of adult human heart function, in just four weeks. Growing human cardiac tissue that behaves like native heart muscle would be transformative for biomedical research, enabling researchers to study human physiology and model heart diseases under fully controlled conditions.

While today scientists can grow many tissues, including the heart muscle, from stem cells taken from a small blood sample of any of us, current bioengineered tissues fail to show some of the most critical hallmarks of adult human heart function.

Researchers have not been able to build a cultured heart muscle mature enough to be useful for medical research until now. The study was published today in Nature