All news from Anaesthesiology

Minimally invasive aortic valve replacements: low mortality and stroke risks in patients

According to the findings published in the Journal of Thoracic and Cardiovascular Surgery, researchers showed low mortality and stroke risks in all age groups within 30 days of surgery. The findings were based on analysis of over 1,000 minimally invasive aortic valve replacements and above 400 additional associated procedures performed over a period of five-and-a-half year by Dr. Joseph Lamelas, from Baylor College of Medicine.

Women with Large Breasts Undergoing Mastectomy: Safe and Effective Method

Women undergo risk-reducing mastectomy for preventing breast cancer, but reconstruction appears to be challenging in those with larger breasts. The researchers then developed a two-stage approach where initially breast size is reduced, ‘pre-shaped’ and then followed by mastectomy and reconstruction. This method was found safe and effective; findings were published in Plastic and Reconstructive Surgery, the official medical journal of the American Society of Plastic Surgeons (ASPS).

For solid tumors combination therapy was effective in the lab as well as the in-clinics

According to the two studies, use of alisertib along with the drug TAK-228 was more effective against triple-negative breast cancer and solid tumors than either drug alone. The first study showed that mTOR is important for the cancer cells to maintain senescence state, while the second study reported the results of an ongoing phase 1 dose-escalation clinical trial of this combination in patients with advanced solid tumors.

Survival benefit in OHCA with early use of mechanical CPR

According to the Singapore study, the mechanical cardiopulmonary resuscitation (CPR) devices could offer survival benefit than manual CPR only if it’s used early on-site to manage OHCA. A potential, randomized, multicentre study was carried out by the researchers over 12 months. LUCAS 2 devices were used in 14 ambulances and manual CPR was used in 32 ambulances to manage OHCA. The primary outcome was the return of spontaneous circulation (ROSC). The secondary outcomes included survival at 24 hours, survival at discharge from hospital and survival at 30 days.