All news from Anaesthesiology

Advances in the Understanding of Inflammatory Bowel Disease

A new study on Crohn's disease published in the journal PLOS ONE revealed that patients with debilitating inflammatory bowel disease (IBD) have insufficient protein level derived from the SHIP1 gene. The findings have the potential implication for IBD. A simple blood test in patient with Crohn's disease could detect SHIP1 protein level and help the doctors to determine the treatment approach.

Hematopoietic Stem Cell Transplantation: Improved Transient Apoptosis Inhibition in Donor Stem Cells

Researchers have proved that hematopoietic stem cell (HSC) transplants could be improved by giving treatments, which temporarily prevent stem cells from dying. These can be useful for patients who need HSC transplants and leukaemia and lymphoma patients. They are treated for fewer donor stem cells when potential adverse side effects were limited. This study was published in The Journal of Experimental Medicine.

Brain Inflammation Pattern Explains HIV?Associated Neurocognitive Impairment on Antiretroviral Treatment

The combination of antiretroviral therapy (cART) for the patient infected with HIV causes impairment in the neurocognitive function (neuroHIV). So the researchers from John Hopkins University looked at the underlying pathology and found an unusual lymphocyte-dominant inflammation that might lead the cognitive decline in cART-treated HIV patients. The study was published in The American Journal of Pathology.

Protein changes essential in normal muscle development and its function

Researchers at Baylor College of Medicine elucidated the process involved in the development of the muscle. Using a mouse model, they showed that a group of genes involved in calcium handling undergoes alternative splicing, a process that changes the type of protein the genes produce as muscles transition from newborn to adult. These protein changes are vital for normal functioning of the muscle, else leads to muscle disorders such as myotonic dystrophy, study published in eLife.

Prevalence of Burnout among Palliative Care Clinicians

A research team conducted a study to explore burnout in palliative care clinicians. Burnout is a psychological state characterized by emotional and physical exhaustion, depersonalization, and a low sense of personal accomplishment. According to an earlier study, more than 62% palliative care clinicians are suffering from burnout. 

Arthritis Drug Could Treat Blood Cancer Patients, a New Discovery

Polycythemia Vera (PV) is a type of blood cancer, which causes an overproduction of red blood cells. Patients suffer from itching, headaches, weight loss, fatigue and night sweats. Every year in the UK, around 3,000 people were diagnosed with PV. Existing treatments provide little relief from symptoms but do not slow the progression of the disease. The findings of the study were published in Haematologica.


Impaired Olfaction Linked To Malnutrition in Patients With Chronic Kidney Disease

A new research shows that there is an impaired ability to smell in the patients with chronic kidney disease (CKD) which is linked with worse nutritional status. The study outcomes are significant as malnutrition is a major complication of CKD, which in turn contributes to inferior quality of life, poor overall health, and even premature death. The findings will be published in the Journal of the American Society of Nephrology (JASN).

Angiogenesis of the Retina: Averted by Genome Editing with CRISPR-Cas9

The researchers, using a novel gene-editing technique with CRISPR-Cas9 prevented angiogenesis of the retina in the mice successfully. The researchers from Schepens Eye Research Institute of Massachusetts Eye and Ear, using a novel gene-editing technique with CRISPR-Cas9 have positively prevented mice from developing angiogenesis of the retina (sensory tissue at the back of the eye). This lead to the development of new therapies for eye conditions marked by pathological intraocular angiogenesis, a report published in Nature Communications.