Antibodies are essential in biological research and medical diagnostics. However, researchers have developed secondary nanobodies that could replace the most-used antibodies and may significantly decrease the number of animals in antibody production.
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The researchers from Ghent University Hospital finds that osteitis or bone marrow edema as measured by magnetic resonance imaging was present in healthy people. However, it did not significantly increase due to intense physical activity. The study was published in the recent issue of Rheumatology.
Researchers found a new treatment for a rare and often incurable condition called dermatomyositis(DM), this has reduced the severity of disease in patients. They conducted a test on 22 patients; these patients were treated with a drug called anabasum or placebo. After trailing on them, 11 patients showing with a drug improvement in the trial period. They showed less skin disease and the quality of life was better. These findings are done at the American College of Rheumatology.
The team, led by ICREA research professor Gian Gaetano Tartaglia at the CRG, is using genomics to advance our understanding of Parkinson´s disease. The study was published in the Nucleic Acids Research. The researchers have discovered a mechanism that regulates the expression of alpha-synuclein, a protein linked to Parkinson´s disease and multiple system atrophy (MSA).
The scientist from University of Colorado Anschutz Medical Campus and Northwestern Medicine led the first study to evaluate the effects of high-intensity exercise on patients with Parkinson's disease. They found that high-intensity exercise three times a week is safe for individuals with early-stage Parkinson's disease and decreases worsening of motor symptoms. The study was published in the December issue of JAMA Neurology,
Armin Arshi, MD, of the David Geffen School of Medicine at UCLA and colleagues conducted the studies.According to the new research, when compared to conventional inpatient surgery, patients undergoing outpatient total knee arthroplasty (TKA) experience higher rates of certain complications, including infections, repeat surgery, and blood clots.The study reports were published in The Journal of Bone & Joint Surgery
Children and teens who experience abuse, bullying, neglect or witness violence and other forms of adversity are more likely to develop heart and blood vessel diseases as adults. Unhealthy responses to stress (such as overeating), mental health problems and disruptions in basic biologic processes may underlie the increased risk. The findings are according to a new scientific statement by the American Heart Association published in the Association's journal Circulation.
Researchers at The Wistar Institute have found that combining PARP inhibitors, poly ADP ribose polymerase enzyme inhibitor recently approved for the treatment of BRCA-mutant ovarian cancer, with another small molecule inhibitor was effective to treat ovarian cancers without BRCA1 and BRCA2 gene mutations. This study was published online in Cell Reports.
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have now uncovered new insights into the regulatory network behind that termination. The study, led by TSRI Associate Professor Brock Grill, PhD, was recently published in the journal Development. Using the nematode worm C. elegans as a model, Grill and his colleagues found for the first time that growth cone collapse prior to axon termination is protracted as the growth cone transitions from a dynamic to a static state.
Inappropriate blood transfusions given in the emergency department (ED) to individuals with iron deficiency anemia were reduced by implementing a set of relatively simple strategies. The results of this quality improvement project here at the at the American Society of Hematology (ASH) 2017 Annual Meeting.
A new study revealed that Telemonitoring of young patients with inflammatory bowel disease (IBD) could save healthcare resources without increasing the risk of flares. The study published in the Journal of Crohn’s and Colitis.