All news from Anaesthesiology

Insights Into Understand Cartilage Development

Anyone with arthritis can appreciate how useful it would be if scientists could grow cartilage in the lab. To this end, Keck School of Medicine of USC scientists in the USC Stem Cell laboratory of Denis Evseenko, MD, Ph.D., collaborated with colleagues at several institutions to provide new insights into how gene activity drives the development of cartilage. Their findings appear today in Nature Communications

Pathogens More Susceptible to Antibiotics, Mechanism Uncovered

Scientists at the Research Institute of the McGill University Health Centre (RI-MUHC) have identified new means of fighting drug-tolerant bacteria, a growing global threat as menacing as drug-resistant microbes. Little is known about the mechanisms leading to tolerance, a strategy that makes bacteria "indifferent" to antibiotics and almost "un-killable," which results in chronic infections extremely difficult to treat and cure.

Prevalence Of Diagnosed Type 1 And Type 2 Diabetes Among US adults

A new study from the University of Iowa finds that type 2 diabetes remains overwhelmingly the most common type of diabetes diagnosed in American adults who have the disease. The study found that 8.5% of American adults have been diagnosed with type 2 diabetes and 5% with type 1 diabetes.

Among those who are diagnosed with diabetes, 91.2% have type 2 diabetes and 5.6% have type 1 diabetes. The study was published in the British Medical Journal.

Stem Cell Could Improve Bone Marrow Transplantation

New findings of hematopoietic stem cells which give rise to all blood cells could lead to improvements in bone marrow transplantation. The liver is the surprising source of a growth factor that keeps bone marrow stem cells healthy. In bone marrow transplantation often used to treat blood cancer healthy bone marrow cells are transferred to a patient to replace diseased cells.

The study, published in the latest issue of Science, uncovered the source of a key growth factor that, in mice, keeps blood-forming hematopoietic stem cells (HSCs) in a healthy state inside bone marrow. Without the growth factor, HSCs cannot maintain themselves or create new blood cells

Carbon Nanodots: Effect of Ultrafine Pollution Particles on Lung Tissues Mimicked

Epidemiological studies have established a strong correlation between inhaling ultrafine particles from incomplete combustion and respiratory and cardiovascular diseases. Still, relatively little is known about the mechanisms behind how air particulates affect human health. New work with carbon nanodots seeks to provide the first model of how ultrafine carbon-based particles interact with the lung tissues.

Modified Nucleotide Moving Through The Confines Of a DNA Polymerase

New findings at the molecular level of polymerases can be used for genome sequencing and other areas of molecular biology-based diagnostics. Complex biological systems can be described as a network of chemical processes that take place in molecules.

The scientists of the "Chemie" research initiative at the University of Konstanz are working together in an equally active network with dynamic interconnections both subject-specific and interdisciplinary. The research results were published on 17 September 2018 in the Proceedings of the National Academy of Sciences (PNAS).