The proposal by the European Athletics Council to disregard all athletic world records set before 2005 should be abandoned, insist experts in an editorial published online in the British Journal of Sports Medicine.
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The development of a vaccine that protects against HIV infections has proven extraordinarily difficult. One of the reasons is that naïve precursor B cells that can give rise to mature B cells producing broadly neutralizing antibodies are considered to be exceedingly rare within the average human. The study is published online the journal Immunity.
Scientists from the Max Planck Institute for Heart and Lung Research (MPI-HLR) in Bad Nauheim have now shown that reduced activity of the transcription factor FoxO3 plays a key role in the development of pulmonary fibrosis. In research on mice, the progress of the disease was able to be halted using drugs that boost FoxO3 activity. The researchers are hoping they may have found a possible approach to treatment.
New study by University of Wisconsin-Madison researchers identified the structural basis for how tightly bound protein complexes are broken apart to become inactivated. The structure explains why the complexes are less active in some cancers and neurodegenerative diseases, and offers a starting point to identify drug targets to reactivate it. This recent study is published in Nature Communications.
To investigate whether symptomatic treatment with non-steroidal anti-inflammatory drugs (NSAIDs) is non-inferior to antibiotics in the treatment of uncomplicated lower urinary tract infection (UTI) in women, thus offering an opportunity to reduce antibiotic use in ambulatory care.
Bacteriophages, or simply phages , are viruses that infect and replicate within bacteria, and they hold considerable potential for antibiotic-resistance and other threats to human health. Timed with the hundredth anniversary of their discovery, a new review published in the British Journal of Pharmacology examines the challenges and opportunities of developing phages as health-promoting, commercially-viable biopharmaceuticals.
According to long-term data from the PROMISE trial, Both maternal antiretroviral therapy (mART) and prolonged infant nevirapine prophylaxis (iNVP) safely help to prevent breastfeeding mothers from passing HIV-1 to their infants. The study was published in the Journal of Acquired Immune Deficiency Syndromes.
According to a new analysis published in JAMA Internal Medicine, preventing a preterm birth could cost as little as $200 or as much as $20,000, depending on which one of two medications doctor orders. The results are based on a comparison of medication costs and pregnancy outcomes among > 3,800 women treated with either a compounded, made-to-order form of the synthetic hormone progestin known as 17P or with a brand-name pre-packaged version of the same medication.
Researchers have invented a biochemically formulated patch of dissolvable microneedles for the treatment of type 2 diabetes. The biochemical formula of mineralized compounds in the patch responds to blood chemistry to manage glucose automatically. In a proof-of-concept study performed with mice, the researchers showed that the chemicals interact in the bloodstream to regulate blood sugar for days at a time.
A new research evaluated that the effect of the increased coverage on service utilization should consider whether differential knowledge about services might affect individual responses to changes in price.
"The Indian healthcare sector needs to reshape the paradigm of care and create an environment of regular introspection to achieve the goal of Healthy India. To undertake this journey, we need to redefine the health system and clearly lay out the preferred path for several key aspects, including insurance coverage, adherence to treatment and care protocols, regulations, price control, payment models, technology adoption and ethics," said NATHEALTH in a statement.