All news from Anaesthesiology

HIV vaccine: Overcoming difficulties in its development

The development of a vaccine that protects against HIV infections has proven extraordinarily difficult. One of the reasons is that naïve precursor B cells that can give rise to mature B cells producing broadly neutralizing antibodies are considered to be exceedingly rare within the average human. The study is published online the journal Immunity.

Reduced Activity of Transcription Factor can Trigger Pulmonary Fibrosis

Scientists from the Max Planck Institute for Heart and Lung Research (MPI-HLR) in Bad Nauheim have now shown that reduced activity of the transcription factor FoxO3 plays a key role in the development of pulmonary fibrosis. In research on mice, the progress of the disease was able to be halted using drugs that boost FoxO3 activity. The researchers are hoping they may have found a possible approach to treatment.

Breaking up of protein complexes is hard; New study shows

New study by University of Wisconsin-Madison researchers identified the structural basis for how tightly bound protein complexes are broken apart to become inactivated. The structure explains why the complexes are less active in some cancers and neurodegenerative diseases, and offers a starting point to identify drug targets to reactivate it. This recent study is published in Nature Communications.

Phages may be Our Best Bet Against Antibiotic Resistance

Bacteriophages, or simply phages , are viruses that infect and replicate within bacteria, and they hold considerable potential for antibiotic-resistance and other threats to human health. Timed with the hundredth anniversary of their discovery, a new review published in the  British Journal of Pharmacology  examines the challenges and opportunities of developing phages as health-promoting, commercially-viable biopharmaceuticals.

Comparison between Branded and Compounded 17-Alpha Hydroxyprogesterone Caproate

According to a new analysis published in JAMA Internal Medicine, preventing a preterm birth could cost as little as $200 or as much as $20,000, depending on which one of two medications doctor orders. The results are based on a comparison of medication costs and pregnancy outcomes among > 3,800 women treated with either a compounded, made-to-order form of the synthetic hormone progestin known as 17P or with a brand-name pre-packaged version of the same medication.

NATHEALTH: Current state of healthcare in India requires action across multiple dimensions

"The Indian healthcare sector needs to reshape the paradigm of care and create an environment of regular introspection to achieve the goal of Healthy India. To undertake this journey, we need to redefine the health system and clearly lay out the preferred path for several key aspects, including insurance coverage, adherence to treatment and care protocols, regulations, price control, payment models, technology adoption and ethics," said NATHEALTH in a statement.