All news from Anaesthesiology

T cells Move Toward Inflamed Tissue Using Membrane Protrusions

According to a new study published in the issue of Cell Reports, helper T cells move toward inflamed tissue using membrane protrusions that stabilize them and provide traction on the vasculature. Using high-resolution microscopy and global molecular analysis, the team shows that immature T cells lack these protrusions but that maturing T-cells switch on a gene expression program to create material to construct them.

Effect of Obesity on Blood-making Stem Cells

New research published in the Journal of Experimental Medicine highlights the pernicious effect of obesity on the long-term health of blood-making stem cells (hematopoietic stem cells). Conducted largely in genetic models of obese mice, it shows obesity causes durable and harmful changes to the hematopoietic stem cell compartment – the blood-making factory in our bodies.Researchers at the Cincinnati Children's Cancer and Blood Diseases Institute conducted the study.

Patients have an important role in shaping kidney disease

In an effort to provide patients the opportunity to share practical health consumer perspectives, the Clinical Journal of the American Society of Nephrology (CJASN) is including Patient Voice editorials that will accompany certain journal articles. In the first editorial, Paul T. Conway, a past recipient of the ASN President's medal, highlights 2 CJASN articles that focus on patient comprehension of how treatments align with their individual interests.

e-STI testing nearly doubles testing uptake

The randomized controlled trial of more than 2,000 people in Lambeth and Southwark was led by the London School of Hygiene & Tropical Medicine and King's College London, in partnership with SH:24, a digital sexual health service. The study found testing uptake was nearly doubled in a group that was invited to use internet-accessed STI testing (e-STI testing) compared to a group which was invited to use existing services at health clinics (50% e-STI testing group compared to 26.6% control group). Participants were free to use any other service or intervention during the study period.