All news from Anaesthesiology

Receiving Right Depression Medication: Predicting Treatment Response

A new study published in the journal PLOS Biology suggests why an antidepressant treatment can alleviate depression in one person but not another. The researchers developed a mouse model that allowed them to identify blood signatures associated with response to antidepressant treatment and could show the importance of the stress-related glucocorticoid receptor in recovery from depression.

IBD: Steroid Use may Increase Thromboembolism Risk

According to a study published in the Journal of Crohn's and Colitis, steroid therapy is associated with an increased risk of venous thromboembolic events in patients with inflammatory bowel disease (IBD), but biological therapy is not . The risk of venous thromboembolism (VTE) is 1.5- to 3-fold higher in IBD patients, compared with non-IBD controls, with most events occurring during acute flare-ups of the disease.

Middle Aged Men’s Heart Older Than Their Actual Ages

A recent analysis led by the Public Health England (PHE) revealed that approximately 10% of the 50-year-olds with a poor lifestyle have a heart of a 60-year-old man. The results suggested that they (who took the Heart Age Test; done to check if people were at risk of heart attack and stroke) could die 10 years before they should if their lifestyle continues in the manner.

A Key Protein Holds Clues for Better Drug Design

Scientists have examined deep into the heart of a key protein used in drug design and discovered dynamic structural features that may lead to new ways to target diseases. A protein called A2A adenosine receptor (A2aAR), is a member of the G-protein-coupled receptor (GPCR) family, which are the targets of roughly 40 percent of all approved pharmaceuticals.

The new, more detailed image of A2aAR's signaling mechanism reveals key parts of its inner workings, including an amino acid that acts like a "toggle switch" to control signaling across the cell membrane. This study was published in the journal Cell.

Non-public EDs prevalent in communities with public hospital

Researchers focuses on improving value in health care delivery through care coordination, and access to care for vulnerable populations. The practice of indirect referrals by non-public emergency departments and their affiliated physicians are prevalent in communities with a public hospital option. Uninsured patients are the most affected. This study was published in Academic Emergency Medicine (AEM), a journal of the Society for Academic Emergency Medicine (SAEM).