The first drug targeting the cause of Huntington's disease was safe and well-tolerated in its first human trial, and successfully lowered the level of the harmful huntingtin protein in the nervous system, according to the UCL Institute of Neurology researchers.
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According to investigators, laboratory-developed tests (LDTs) as well as U.S. Food and Drug Administration-approved companion diagnostics (FDA-CDs) show a high degree of accuracy and comparable performance for three oncology analytes. The study was published in the journal JAMA Oncology.
The normal immune cells called macrophages, which reside in healthy breast tissue surrounding milk ducts, play a major role in helping early breast cancer cells leave the breast for other parts of the body, potentially creating metastasis before a tumor has even developed, according to a study published in the journal Nature Communications.
A study promoting new therapeutic approach, which is "incredibly unique" and is safe and effective in some patients with intractable pain. Low doses of the hormone oxytocin along with the anesthetic ketamine may provide a unique and effective therapeutic approach to some patients with severe intractable pain. Dr Pedersen has found better ways to treat patients with very severe pain.
Scientists from the "Hopp Children's Cancer Center at the NCT Heidelberg" (KiTZ), in collaboration with colleagues from the USA and Canada, have now developed a molecular approach that opens new treatment prospects. The study findings were published in the Nature
In an observational study of patients who were prescribed varenicline (Chantix in the United States/Champix elsewhere, Pfizer) to stop smoking, treatment was associated with increased risk of cardiovascular events, researchers report. Patients in Ontario who visited the emergency room (ER) or were hospitalized for a cardiovascular event(MI or stroke) within a year before or after filling the first prescription for varenicline were 34% more likely to have this event during the 12-week varenicline-therapy period as opposed to before or after.
According to this study, researchers assessed the Mathematical models have proven the risk of the on-going pneumonic plague epidemic in Madagascar spreading elsewhere in the world is limited, with the estimated number of exported cases staying below 0.1 person in each country between August 1 and October 17. This was the world's first real-time study into the epidemiological dynamics of the largest ever pneumonic plague epidemic in the African nation.
Mycoplasmas are very simple bacteria. Mycoplasma agalactiae is one of the most important pathogenic mycoplasma species in sheep and goats. By specifically inactivating a certain area in the genome of this pathogen the scientists made an important step forward, especially due to the fact that mycoplasmas are generally difficult to manipulate genetically .
A new study published in the journal Nano Letters has found that one of the most common medications to prevent osteoporotic fractures hinder the repair of damaged tissue , causing mineralization of bone cells. The discovery may be important for understanding the effect of medication on bone quality.
A new study revealed that association between higher childhood blood lead levels and a greater risk for criminal behaviour (a dose-response relationship) in settings where blood lead levels are similar across low and high socioeconomic status was not clear.
A recent study has found 16 aging, communist-era lignite plants in areas of former Yugoslavia emit as much pollution as all the European Union's 296 power plants combined. With an eye on future EU membership, the governments of ex-Yugoslav republics have pledged to tackle emission levels. Sarajevo, Tuzla and Zenica in Bosnia, as well as Kosovo's capital Pristina, suffer from similar high air pollution. An annual winter scourge in the Western Balkans blamed on a mix of coal burning, ageing industry and high-polluting emissions from older vehicles.