All news from Anaesthesiology

Dupilumab Beneficial in Patients With Severe Atopic Dermatitis

A Phase 3 trial of Dupixent (dupilumab; Sanofi and Regeneron) in adolescent patients found that monotherapy resulted in significant improvements in the signs and symptoms of atopic dermatitis. The findings were presented at the recent European Academy of Dermatology and Venereology (EADV) Congress.

Dupixent is an interleukin-4 and interleukin-13 inhibitor and is currently approved to treat moderate-to-severe atopic dermatitis in adults whose disease is not adequately controlled with topical prescription therapies. 

Enhancing Clinical Study Design and Generate Real-world Evidence

PAREXEL International Corporation, a leading innovator of global biopharmaceutical services, and Datavant, Inc., a healthcare technology company focused on enabling the secure de-identification and linking of healthcare datasets, today announced they are partnering to enhance clinical study design and operations, as well as the generation of real-world evidence.

As part of PAREXEL's focus on providing innovative scientific and clinical data strategies, the collaboration will enable the linking of healthcare data from a variety of real-world and clinical study data sources to improve drug development and commercialization processes.

Association Between Artificial Gravity And Cardiovascular Deconditioning Of Spaceflight

Spaceflight-induced physiological deconditioning resulting from the decreased gravitational input decreased plasma volume, and disruption of regulatory mechanisms is a significant problem in returning astronauts as well as in normal aging.

Here we review the effects of a promising countermeasure on cardiovascular systems of healthy men and women undergoing Earth-based models of space-flight. This countermeasure is produced by a centrifuge and called artificial gravity (AG).

Numerous studies have determined that AG improves orthostatic tolerance (as assessed by various protocols) of healthy ambulatory men, of men deconditioned by bed rest or by immersion (both wet and dry) and, in one case, following spaceflight