All news from Anaesthesiology

Specific Brain Circuit Controls Social Behavior

A new study published in Biological Psychiatry  has identified a key brain region of the neural circuit that controls social behavior. Increasing the activity of this region, called the habenula, led to social problems in rodents, whereas decreasing activity of the region prevented social problems. The improved understanding of altered brain function could help develop new targeted therapeutics for autism spectrum disorder.

Newly Solved Glucagon Receptor Structure Offers Drug Design

According to new study, scientists at SIMM determined the crystal structure of GCGR in complex with a glucagon analogue and partial agonist NNC1702. This structure reveals, for the first time, the molecular details of a class B GPCR binding to its peptide ligand at high resolution and unexpectedly discloses the structural complexity that governs receptor activation, so significantly expanding the understanding of class B GPCR signal transduction. The study was published in Nature.

Alzheimer’s Drug Turns Back a Cellular Clock

The experimental drug J147 is something of a modern elixir of life; it's been shown to treat Alzheimer's disease and reverse aging in mice and is almost ready for clinical trials in humans. A new study, published in the journal Aging Cellreports that the drug, J147, binds to a protein found in mitochondria, the energy-generating powerhouses of cells. In turn, the study showed, it makes aging cells, mice and flies appear more youthful.

New Deep-Learning based Hematological Human Aging Clock Developed

In a research paper published in The Journal of Gerontology, the authors present a novel deep-learning based hematological human aging clock, a biomarker that predicts the biological age of individual patients. The developed model predicts the age better than models tailored to the specific populations highlighting the differences of subregion-specific patterns of aging. In addition, the developed clocks were shown to be a better predictor of all-cause mortality than chronological age.