The addition of hyperthermic intraperitoneal chemotherapy to interval cytoreductive surgery prolonged recurrence-free survival (RFS) and overall survival (OS) without increasing toxicity among patients with stage III epithelial ovarian cancer, according to randomized open-label phase 3 study results published in The New England Journal of Medicine.
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A unique platform that resulted in a promising HIV vaccine has also led to a new, highly effective vaccine against tuberculosis that is moving toward testing in humans. The new vaccine completely protected 41% and reduced overall TB disease by 68% in vaccinated rhesus macaques, according to a study published as an Advanced Online Publication of Nature Medicine.
About 40% of older women and up to 35% of older men live with distressing urinary symptoms, including difficulty with bladder control and urinating (sometimes known as "voiding"), which often compromise the quality of life and overall health.
The lack of truly effective and safe therapies for these challenges stems from insufficient knowledge of the biological mechanisms for urinary control, the impact of aging and disease on urinary control, and the relationships of symptoms to urinary health and overall well-being.
Posttraumatic Stress Disorder (PTSD) patients treated with as few as five sessions of trauma-focused psychotherapy find it equally effective as receiving 12 sessions.
Study from the University of Illinois and Mayo collaboration has proved a novel gene expression analysis technique that can accurately measure levels of RNA quickly and directly from a cancerous tissue sample while conserving the spatial information across the tissue. The study published in the Nature Communications.
A new study, published in the journal Proceedings of the National Academy of Sciences, described a machine learning algorithm that uses brain scans to predict language ability in deaf children after they receive a cochlear implant. This study's novel use of MRI and artificial intelligence to understand brain structure underlying language development has broad-reaching implications for children with developmental challenges.
Greg Gloor, together with a team of scientists at Western, McMaster and Guelph universities, worked to address the problem by developing what he calls "highly targeted nuclear warhead" molecule to modify an individual's microbiome and hone in on eradicating only bad bacteria , when they invade .
Exposure to non-ionizing radiation from devices like smartphones, Bluetooth devices and laptops doubles the risk of miscarriage in pregnant women, according to a study published in the journal Scientific Reports.
UConn engineers have created a biodegradable pressure sensor that could help doctors monitor chronic lung disease, swelling of the brain, and other medical conditions before dissolving harmlessly in a patient's body. The UConn research is featured in the current online issue of the Proceedings of the National Academy of Sciences.
Scientists from Michigan State University seek to investigate and potentially identify the brain mechanisms related to psychosis associated with schizophrenia. Researchers suspect these psychotic symptoms may be related to faulty signaling between regions of the brain that are involved in producing movement and regions of the brain involved in sensation.
A new study has shown that primary care physicians (PCPs) continue to prescribe medications for behavioural and psychological symptoms of dementia (BPSD) because they view them as safer and more effective than controlled studies report. PCPs use drugs for symptoms with a direct threat of harm but also to meet patient-oriented goals, including easing patient suffering.
Renal and hepatotoxicity of diglycolic acid (DGA) has been described with in vitro cellular models as well as in vivo animal and human systems. The possibility of diglycolic acid (DGA) being toxic to other organs, such as the heart, has not been well investigated. A human case report identified the heart as a potential target organ of DGA, but an in-house in vivo rat study neither found gross nor microscopic pathological changes following repeated oral DGA exposure.