In a study published in Nature, scientists have found that the role of Myc (generation of new blood cells in bone marrow and role in cancer) is determined by a distant section of DNA that contains a cluster of gene enhancers. In certain blood cancer cells, this cluster has been altered, which affects Myc activity and thereby accelerates cancer growth and affects how cancer responds to chemotherapy. This cluster of enhancers might, therefore, be a suitable target for the treatment of blood cancer.
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A study from working on regulation of the risk elevated lipid levels (hyperlipidemia/hypertriglyceridemia), hypertension, metabolic syndrome, polycystic ovarian syndrome, diabetes, non-alcoholic liver disease, and elevated liver enzyme levels in children with and without psoriasis, after accounting for obesity.
Researchers demonstrated the combined positron emission tomography / computed tomography ( PET / CT ) scanning early in treatment could identify whether the therapy will benefit a particular patient. As the therapy has potentially serious side effects, early determination of ineffectiveness could avert unnecessary risk exposure and provide the option of a different treatment.
A Food and Drug Administration (FDA) advisory panel voted against recommending ciprofloxacin dispersion for inhalation, to treat adult non-cystic fibrosis bronchiectasis (NCFBE) patients who have chronic lung infections with Pseudomonas aeruginosa.
Social reformer Raghunath Dhondo Karve was well ahead of his time when he pioneered family planning in Mumbai in the 1920s. Independent India’s first government caught up in 1952 when it started the world’s first family planning programme. The recently released report on the fourth round of the National Family Health Survey (NFHS-4), carried out in 2015-16, shows where it has succeeded—and where shortcomings remain.
A new study published in the Journal of the American College of Surgeons has revealed that total pancreatectomy with islet autotransplantation (TPIAT) is a durable treatment for selected chronic pancreatitis patients. The most significant finding is that patients with genetic pancreatitis have superior outcomes and clearly benefit from TPIAT.
According to this study, researchers declared in a pre-anaesthetic clinic (PAC), as in any clinical service, patient satisfaction is important. This may be influenced by many factors. The main factor adversely affecting patient satisfaction is time spent in the clinic. Total time spent in PAC can be split into two parts: waiting time and consultation time, which have been defined. Patients needing emergency surgery are also not seen as they are assessed in the operating theatre itself.
New research published in the journal Clinical Cancer Research reported that researchers from King's College London have found a way to boost the immune system to help it fight back against cancer. The breakthrough involves the first ever use of a combination of chemotherapy and a drug being trialled as a treatment for neonatal jaundice, that together helps kick-starts the body's natural defences.
According to the Norwegian scientists report, while it is thought to have killed between 30-60% of Europe's population, but the Black Death plague may not have been spread by flea-infested rats. The study was published online in the Proceedings of the National Academy of Sciences.
In this study, researchers have developed the first map of gene regulation in human neurogenesis, the process by which neural stem cells turn into brain cells and the cerebral cortex expands in size. The scientists identified factors that govern the growth of our brains. Brain development is guided by the expression of genes in certain brain regions or cell types, as well as during specific time frames.
A study lead by Laura N. Medford-Davis, MD, MS, an assistant professor of emergency medicine at Baylor College of Medicine, and a healthcare consultant. Uninsured patients are the most affected. The practice of indirect referrals by non-public emergency departments and their affiliated physicians are prevalent in communities with a public hospital option. This study published in the issue of Academic Emergency Medicine (AEM), a journal of the Society for Academic Emergency Medicine (SAEM).
In this study, researchers declared that antimicrobial resistance (AMR) is a global health issue. To minimize this threat to astronauts, who may be immunocompromised and thus at a greater risk of infection from antimicrobial resistant pathogens, a comprehensive study of the ISS “resistome’ was conducted. Using whole genome sequencing (WGS) and disc diffusion antibiotic resistance assays, 9 biosafety level 2 organisms isolated from the ISS were assessed for their antibiotic resistance.