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Cystic Fibrosis: Delayed Neutrophil Apoptosis Enhances NET Formation

The researchers demonstrate that Cystic fibrosis (CF) neutrophils have prolonged survival secondary to decreased apoptosis, and this is likely a primary defect in CF neutrophils. Increased neutrophil extracellular traps (NET) formation by CF neutrophils is a consequence of a failure to engage in apoptosis and can be targeted by CDKi drugs.

An intrinsic delay in neutrophil apoptosis enhances NET formation in CF and consequently inflammation, representing a novel target for the development of future anti-inflammatory therapies.