All news from Anaesthesiology

Seizure Cycles May Follow Circadian Rhythms

The timing of epileptic seizures may be linked to natural circadian rhythms, which may help to guide future treatment options, new research suggests. In what is believed to be the largest study of individual patients' seizure cycles, researchers found that most seizures followed a circadian rhythm.

Some patients experienced weekly and 3-weekly seizure cycles, and some had a combination of daily, weekly, or longer cycles associated with their seizures. This will help guide therapy, and may ultimately allow more tailored therapies to be provided," Cook said. The study was published in Lancet Neurology.

Ranolazine in High-Risk Patients With Implanted Cardioverter-Defibrillators

For high-risk patients with implantable cardioverter-defibrillators (ICDs), ranolazine does not significantly reduce the risk of ventricular tachycardia (VT) or ventricular fibrillation (VF) requiring appropriate ICD therapy, or death. The study was published in the Journal of the American College of Cardiology. Researchers randomized high-risk ICD patients with ischemic or nonischemic cardiomyopathy to 1,000 mg ranolazine twice daily (510 patients) or placebo (502 patients).

Study of Protein 'Trafficker' Provides Insight Into Autism and Other Brain Disorders

In the brain, as in business, connections are everything. To maintain cellular associates, the outer surface of a neuron, its membrane, must express particular proteins—proverbial hands that reach out and greet nearby cells. And, like a creepily long handshake, surface molecules can overstay their welcome: A protein that lingers too long on the membrane may compromise the connections, or synapses, between cells